ER、PR、C-erbB-2、P53及Ki-67在乳腺癌组织中表达的相关性研究

Expression correlation of ER,PR,C-erbB-2,P53 and Ki-67 genes in breast cancer

目的探讨乳腺癌组织中ER、PR、C-erbB-2、P53及Ki-67的表达情况及它们的相关性。方法采用免疫组化检测138例乳腺癌组织的ER、PR、C-erbB-2、P53及Ki-67的表达,并对它们与临床病理特征的关系以及它们之间的表达相关性进行分析。结果 ER、PR、C-erbB-2、P53和Ki-67阳性表达率分别为62.31%、59.42%、50.72%、43.47%、60.14%。ER、PR阳性表达与肿瘤大小,淋巴结转移无相关性,与组织学分级和病理分期相关。C-erbB-2、Ki-67与有无淋巴结转移、肿瘤病理分期相关(P均<0.05),Ki-67还与肿瘤组织分级相关(P<0.05)。而P53与乳腺癌组织病理特征无明显相关性。ER与PR表达呈正相关,与P53阳性表达无明显相关性,与C-erbB-2、Ki-67表达呈负相关(P均<0.01)。Ki-67、P53、C-erbB-2表达呈正相关(P<0.05)。结论检测乳腺癌组织的ER、PR、C-erbB-2、P53及Ki-67的表达情况有助于了解乳腺癌的生物学行为,为乳腺癌的个性化治疗提供依据,对预后评估有重要意义。

Objective： To investigate the expression and relationship of ER, PR, C-erbB-2, P53 and Ki-67 in breast cancer. Methods： The expressions of ER, PR, C-erbB-2, P53 and Ki- 57 in 138 cases of breast cancer tissues were deter- mined by immunohistochemical staining. The correlations of clinical and pathological features with the expression of ER, PR, C- erbB-2, P53 and Ki-67 were retrospectively analyzed. Results： The positive expressions of ER, PR, C-erbB-2, P53 and Ki-67 was 62.31%, 59.42%, 50. 72%, 43.47% and 50.14%. The expressions of ER, PR in breast cancer samples were correlated with the histopathology grade and pTNM stages （ P 〈 0.05 ）. The expressions of C-erbB-2 and Ki- 67 were positively correlated with the lymph node metastasis and pTNM stages（ P 〈 0.05 ）. The expression of ER had a sig- nificantly positive correlation with PR （ P 〈 0.05 ）, had no correlation with P53 and had a negative correlation with C-erbB- 2 and Ki- 67 （P 〈 0.01 ）. The expressions of C-erbB-2, P53, Ki- 57 had an insignificantly positive correlation （P 〈 0.05 ） Conclusion： The detection of ER, PR, C-erbB-2, P53 and Ki- 67 protein expression in breast cancer is helpful for a bet- ter understanding of the biological behavior of breast cancer, and significant for individual treatment and prognostic evaluation.