氟西汀联合罗布麻治疗冠心病并焦虑症的临床观察

目的观察氟西汀联合罗布麻与氟西汀单药治疗冠心病并发焦虑症的疗效及安全性。方法 120例冠心病合并焦虑症患者随机分为两组,分别采用氟西汀联合罗布麻及单药氟西汀治疗12周,采用汉密尔顿焦虑量表(HAMA)和抑郁量表(HAMD)及副反应量表(TESS)评定疗效及不良反应。结果氟西汀联合罗布麻组较单药氟西汀组疗效好,起效时间明显较早,氟西汀联合罗布麻组于第1周末两种量表评分均开始显著下降,而氟西汀组下降不明显,在1、2周末两组相比差异有显著性(P<0.01)。不良反应则基本一样。结论氟西汀联合罗布麻治疗冠心病并发焦虑症较单用氟西汀效果好,起效快,患者易于接受。

Objective Observe prozac joint apocynum and prozac single drug treatment of coronary heart disease and anxiety disorders safety and efficacy.Methods 120 patients with coronary heart disease with anxiety disorders were randomly divided into two groups,we adopt prozac joint apocynum and single drug prozac treatment for 12 weeks.Using the Hamilton Anxiety Scale（HAMA） and Depression Scale（HAMD）,and the reaction of scale（TESS） to evaluate the curative effect and adverse reaction.Results Fluoxetine combined with Apocynum group than the single drug fluoxetine efficacy,onset time significantly earlier,fluoxetine combined with Apocynum group in the first weekend of two scale score were beginning to decline significantly,whereas fluoxetine goup,in 1,2weekend two group there was a significant difference（P0.01）.Conclusion Fluoxetine combined with bluish dogbane in treatment of coronary heart disease complicated with anxiety than fluoxetine only good effect,fast effect,and easy for patients to accept.