河南省青年食管癌家族史及环境和行为影响因素

Impact of family history,smoking,drinking and environmental factors on esophageal cancer in young patients from Henan

目的:探讨河南省青年食管癌发病的影响因素。方法:采用问卷调查方法,随机抽取同期2445例青年健康人群与1405例青年食管癌患者人群,比较2组性别、家族史、高低发区、体质指数(BMI)、吸烟喝酒情况的差异,分析危险因素。结果:青年食管癌患者中男性多于女性,家族史阳性(OR=25.616,95%CI=20.431～32.117)是青年食管癌的主要危险因素,其次是高发区(OR=6.440,95%CI=4.791～8.655)和BMI<18.5kg/m2(OR=5.656,95%CI=1.433～22.319),而BMI>24kg/m2为保护因素(OR=0.094,95%CI=0.018～0.493)。结论:高发区家族史阳性的男性更易患食管癌。

Aim：To analyze the pathogenic factors associated with esophageal carcinoma in young people（≤40 years）in Henan province.Methods：Applying the questionnaire survey to compare the difference between gender,family history,high-low incidence area,body mass index（BMI）,smoking,and alcoholic drinking in 1 405 young people with esophageal carcinoma and 2 445 young healthy people,so as to analyze the dangerous factors of the esophageal cancer.Results：Incidence of esophageal carcinoma in men was higher than that in women,positive family history（OR=25.616,95%CI=20.431～32.117） was are the major dangerous factor of the esophageal cancer,the second and third were high incidence area（OR=6.440,95%CI=4.791～8.655） and BMI18.5 kg/m2（OR=5.656,95%CI=1.433～22.319）,while BMI24 kg/m2 reduced the risk of esophageal carcinoma in young adults.Conclusion：Young men with positive family history in high incidence area in Henan province are inclined to develop esophageal carcinoma.