急性冠脉综合征患者血清内脂素和脂联素水平分析

Analysis of visfatin and adiponectin in patients with acute coronary syndrome

目的:分析急性冠脉综合征(ACS)患者血清内脂素、脂联素水平,探讨其与ACS的关系。方法:选取不稳定性心绞痛(UAP组,n=39)、急性心肌梗死(AMI组,n=33)患者,另选取经冠脉造影排除冠心病的30例住院患者作为对照组,测定并分析3组血清脂联素、内脂素、C反应蛋白水平及与血糖、血脂的关系。结果:3组血清脂联素、内脂素、C反应蛋白、血脂差异均有统计学意义(P均<0.001)。ACS组血清内脂素水平与C反应蛋白、甘油三酯(TG)、低密度脂蛋白(LDL)及总胆固醇(TC)呈正相关,与脂联素、高密度脂蛋白(HDL)呈负相关;血清脂联素水平与C反应蛋白、TG、LDL及TC呈负相关,与HDL呈正相关。结论:内脂素、脂联素在ACS中发挥的作用相反,共同参与了ACS的发病过程。

Aim：To analyze the serum level of visfatin and adiponectin（APN） in patients with acute coronary syndrome（ACS）,and explore their function in ACS.Methods：A total of 39 patients with unstable angina pectoris（UAP）,33 patients with acute myocardial infarction（AMI） and 30 cases excluded coronary disease were subjected to detect serum APN,visfatin,C-reactive protein（CRP）,glucose and lipids.Results：The serum levels of APN,visfatin,CRP,and lipids had significant difference among the three groups（P0.001）.Serum visfatin level was positively correlated with CRP,triglyceride（TG）,low-density lipoprotein（LDL） and total cholesterol（TC）,and negatively correlated with APN,high density lipoprotein（HDL）;the serum APN level was negatively correlated with CRP,TG,LDL and TC,and positively correlated with HDL in ACS group.Conclusion：APN and visfatin play the opposite effect in ACS,and both of them are involved in the pathogenesis of ACS.