帕宁方改善帕金森病患者非运动症状的作用研究

Influence of Paning Decoction on Non-motor Symptoms in Parkinson's Disease

目的观察帕宁方对帕金森病(PD)非运动症状的治疗作用。方法将64例患者随机分成治疗组和对照组,对照组给予美多巴治疗,治疗组加服帕宁方,每日1剂,水煎,分2次服,疗程均为12周。比较两组临床疗效及治疗前后帕金森非运动症状问卷量表(NMSQuest)、帕金森病睡眠量表(PDSS)、汉密尔顿抑郁量表(HAMD)、简明精神状态量表(MMSE)的评分及不良反应。结果与对照组比较,治疗组的NMSQuest、HAMD、PDSS评分差异有统计学意义(P<0.05),而MMSE评分略为升高,但差异无统计学意义(P>0.05),治疗组1例(3.12%)出现胃肠胀气,无其他不良反应。结论帕宁方联合美多巴治疗可以明显改善PD患者非运动症状,提高其生活质量。

Objective To observe the influence of Parting Decoction on non-motor symptoms in Parkinson＇s disease （PD）. Methods Sixty-four patients were randomly divided into two groups, thirty-two in treated group and thirty- two in control group. The patients in the control group were treated with Madopar, and the patients in treated group were treated with Parting Decoction（one dose per day, taking the decoction in two separately times） besides Madopar. The duration of treatment for the two groups were twelve weeks. Therapeutic effect was evaluated after treatment, and we observed the adverse effect and scores of non-motor symptom questionnaire（NMSQuest） , Parkinson＇s disease sleep scale （PDSS）, Hamilton depression scale （HAMD） and mini-mental state examination （MMSE）. Results Com- pared the control group with the treated group, there were significant statistical differences of scores in NMSQuest, HAMD and PDSS（P 〈 0.05）. MMSE score of the treatment group was increased, but there was no significant statistic al difference compared with the control group（P 〉 0.05）. During the treatment, one patient felt flatulence（accounting for 3.12 %） , but no any other adverse reactions appeared. Conclusion The combined treatment of Paning Decoction and Madopar can significantly relieve non-motor symptoms and improve quality of life in PD patients.