盐酸氯普鲁卡因用于连续硬膜外麻醉的临床观察

The Effective Observation of Hydrochloroprocaine in Continuous Epidural Anesthesia

目的:观察3%盐酸氯普鲁卡因在连续硬膜外麻醉中的有效性和安全性。方法:60例在L2～3间隙连续硬膜外麻醉下行腹部及以下手术患者随机分为利多卡因组(对照组,n=30)和盐酸氯普鲁卡因组(实验组,n=30),分别注入2%利多卡因和3%盐酸氯普鲁卡因,术中观察心率(HR)、血压(BP)、呼吸频率(R)、脉搏血氧饱和度(SpO2)的变化,记录麻醉后痛觉消失时间、运动阻滞时间、痛觉恢复时间、运动恢复时间、感觉阻滞平面上界、麻醉质量评分及有无不良反应。结果:两组麻醉前后HR、BP、R、SpO2变化一致,组间比较无显著差异。实验组的痛觉消失时间、运动阻滞时间、痛觉恢复时间、运动恢复时间与对照组比较,差异具有显著性(P<0.05)。两组感觉阻滞平面相当,差异无显著性。两组麻醉质量0分加1分所占例数的百分比分别为90%和93%。麻醉效果均满意。两组患者均无不良反应。结论:3%盐酸氯普鲁卡因起效快、阻滞效果好、恢复快、无明显不良反应,能安全用于连续硬膜外麻醉。

Objective：To investigate the efficacy and safety of 3%chloroprocaine hydrochloride in continuous epidural anesthesia.Methods：60 patients undergoing abdominal or the following surgery in continuous epidural anesthesia were randomly divided into two：lidocaine group（control group,n=30） and chloroprocaine hydrochloride group（experimental group,n=30）,which were individually injected into 2% lidocaine and 3%chloroprocaine hydrochloride,The change of heart rate（HR）,blood pressure（Bp）,respiratory rate（R）,oxygen saturation（SpO2） was observed and recorded;The pain disappeared time,motor block time,pain recovery time,sports recovery time,sense block plane ascending boundary,anesthesia quality grade,having or having not adverse reaction after anesthesia were determined.Results：The change of HR,BP,R,SpO2of the two groups was consistent and the two groups showed no significant difference before and after anesthesia;The pain disappearance time,motor block time,pain recovery time,exercise recovery time of the experimental group compared with the control group,the difference was significant（P〈0.05）,with statistical significance;Two groups had almost the same sense block plane,the difference was not significant;Anesthesia effect was both satisfied;Two groups of patients had both no adverse reactions.Conclusion：3%chloroprocaine hydrochloride can be safe for continuous epidural anesthesia because of fast onset of action,blocking effectively,quick recovery,no significant adverse reactions,.