慢性阻塞性肺病患者HP感染状况及致病性研究

Study of HP Infection Status and Pathogenicity of Patients with Chronic Obstructive Pulmonary Disease

目的:对COPD与HP感染的状况及致病性进行研究,为COPD的发病机制及临床治疗提供理论依据。方法:对我院门诊检查确诊的COPD患者147例为观察组,健康体检的115例患者作为对照组,所有纳入对象均进行血清anti-HP-IgG、肺功能检测。结果:COPD组anti-HP-IgG检出率为65.3%,对照组仅为40.0%;COPD组血清anti-CagA及anti-VacA 1种以上亚型阳性者53.7%,而对照组仅为27.0%。差异均有统计学意义。合并HP感染COPD组FEV1%预计值明显低于未合并HP感染COPD组,差异有统计学意义(P<0.05)。COPD重度组HP感染率为81.4%,轻重度组为50.6%,血清anti-CagA及anti-VacA抗体1种以上亚型阳性者重度组高达87.7%,轻中度组为35.9%。差异有统计学意义。结论:COPD患者HP感染率明显高于对照组,切病情越重,感染率越高。HP感染的COPD患者肺功能受损更严重。CagA和VacA高致病性毒素是引起COPD并加重的一个重要原因。

Objective：To study of HP infection status and pathogenicity of patients with chronic obstructive pulmonary disease.Methods：147 cases with COPD in our clinic as observation group,115 healthy cases as controls,serum anti-HP-IgG,pulmonary function testing were tested.Results： Anti-HP-IgG detection rate is 65.3% in the observation group,and only 40.0% in the control group;more than one kind of subtype about serum anti-CagA and anti-VacA1,53.7% was positive in the observation group,only 27.0% in the control group.FEV1% in the COPD group with HP infection significantly lower than the COPD group,there was statistically significant（P0.05）.In severe COPD group,HP infection rate was 81.4% and 50.6% for mild group,one more subtype-positive about serum anti-CagA and antiVacA antibody,severe group was 87.7%,mild group was 35.9%.There was statistically significant.Conclusion：HP infection in patients with COPD was significantly higher,and the more severe the disease,the higher the rate of infection.Lung function impaired more serious in HP infection in patients with COPD.Pathogenic toxins such as CagA and VacA is an important reason to exacerbate COPD.