胰岛素样生长因子结合蛋白2在神经母细胞瘤诊断中的意义

The Significance of Insulin-like Growth Factor Combined with Protein-2 in Diagnosing Neuroblastoma

目的:寻找对神经母细胞瘤临床诊断工作具有指导作用的新型诊断指标,为神经母细胞瘤的诊断和治疗提供新的科学依据。方法:分别对34例确诊神经母细胞瘤患儿和30例正常体检小儿血清中IGF-BP2检测并进行比较;监测神经母细胞瘤术后IGF-BP2水平并与术前比较。结果:神经母细胞瘤组IGF-BP2水平较对照组显著升高;34例手术治疗4周后IGF-BP2水平显著下降,对照组比较差异无统计学意义。结论:神经母细胞瘤患者血清中不但存在IGFBP-2,而且可作为神经母细胞瘤术后监测指标,为神经母细胞瘤的早期诊断、术后监测提供科学依据。

Objective： To study the new diagnostic criteria for neuroblastoma （Nil） to provide new scientific evidence for the disease. Method： 34 cases of neuroblastoma diagnosed in children and 30 normal children with testing of serum IGF-BP2 and compared; Examined in IGF-BP2 paticnts after sugcry and compared with preoperative. Result： Neuroblastoma group IGF-BP2 levels were significantly higher than that in the control group. 34 cases of surgical treatment for 4 weeks after the IGF-BP2 levels decreased significantly in the control group, the difference was not statistically significant （ P〉 0.05）. Conclusion： NB there is not only the serum IGFBP-2, and can be used as indicators for monitoring NB patients for early diagnosis of NB, postoperative monitoring to provide a scientific basis.