酚妥拉明联合丙种球蛋白治疗毛细支气管炎50例临床分析

Clinical Analysis of Phentolamine and Gamma Globulin on Therapy of Bronchiolitis

目的:评价酚妥拉明联合丙种球蛋白治疗毛细支气管炎的疗效与安全性。方法:将毛细支气管炎患儿100例随机分为治疗组和对照组各50例,两组均采用抗感染、化痰、雾化表面激素治疗,治疗组另给予丙种球蛋白400mg/(kg·次),共用3 d,酚妥拉明0.5～1 mg/(kg·次),疗程为3～5 d。比较两组咳嗽、喘憋、气促、哮鸣音及湿啰音消失时间、血气分析及急诊留观天数。结果:治疗组在喘息、气促、肺部体征及血气分析好转等方面明显优于对照组,急诊留观日明显短于对照组(P<0.05)。结论:常规治疗毛细支气管炎基础上加酚妥拉明联合丙种球蛋白可快速缓解临床症状,缩短疗程。

Objective： To explore the clinical effects and safety of phentolamine and gamma globulin on therapy of bronchiolitis. Methods： 100 patients with bronehiolitis were divided randomly into treatment group and control group, and each group was 50 cases. Both groups were treated by anti-infective, eliminate sputum, atomizing surface hormone. The treatment group received gamma globulin 400 mg/Kg 3 days, phentolamine were also used at the dose of 0.5-1mg/kg every time for 3-5 days. Coughing,wheezing,shortness of breath disappeared,wheeze and moist tales disappeared time, blood gas analysis and the number of hospital days were compared between the two groups. Results： The recovery in wheeze,short breath,cyanosis,lung sign and arterial blood gases in the treatment group were significantly better than those in the control group （P〈0.05）.The hospitalization duration in the treatment group was significantly less than that in the control group （P〈0.05）. Conclusion： Plus phentolamine and gamma globulin on the basis of routine therapy canrelease clinical symptom more quick and reduce the course of treatment.