低脂肪饮食对肥胖2型糖尿病患者体质量、血脂及血糖的影响

Effects of low-fat diet on body mass,blood lipids and sugar control in obese patients with type 2 diabetes mellitus

目的观察低脂肪饮食对肥胖2型糖尿病患者体质量、血脂和血糖的影响。方法 120例肥胖2型糖尿病患者随机分配至低脂肪饮食+双胍类药物治疗组(实验组)和常规糖尿病饮食+双胍类药物治疗组(对照组),各60例。在治疗前及治疗1年后检测两组患者的体质量(BM)、糖化血红蛋白(HbA1c)、血压和血脂。结果治疗1年后,实验组与对照组BM分别下降(6.6±1.4)kg和(3.4±1.2)kg,HbA1c分别下降(2.8±0.3)%和(1.0±0.2)%(P<0.05);实验组治疗前总胆固醇(TC)为(4.44±0.82)mmol/L、低密度脂蛋白胆固醇(LDL-C)为(2.56±0.61)mmol/L,治疗后分别为(3.90±0.73)mmol/L、(2.04±0.62)mmol/L(P<0.05),对照组治疗前TC、LDL-C分别为(4.38±0.84)mmol/L、(2.54±0.70)mmol/L,治疗后分别(4.26±0.72)mmol/L、(2.48±0.65)mmol/L,两组治疗后差异比较差异有统计学意义(P<0.05)。结论低脂肪饮食能改善肥胖2型糖尿病患者的体质量、HbA1c及血脂,且疗效优于常规对照组。因此,低脂肪饮食也是治疗肥胖2型糖尿病患者的一种有效方法。

Objective To study the effects of low-fat diet on body mass,blood lipids and sugar in obese patients with type 2 diabetes mellitus（T2DM）. Methods 120 obese patients with T2DM were randomized to the two groups, research group：60 obese patients with T2MD got routine treatment of low-fat associated with biguanides diet,control group：60 obese patients with T2MD were advised on the treatment of the routine diabetic diet. Outcome measures of body mass, HbA1 c,blood pressure and blood lipids were obtained before and after treatment. Results After one year of treatment, body mass and HbA1 c in research group reduced by （6.6±1.4） kg and （2.8± 0.3）%, and those in control group reduced by （3.4±1.2） kg, （1.0±0.2） % （ P 〈0.05）. Before treatment,TC and LDL-C in research group were （4.44±0.82） mmol/L and （2.56±0.61） mmol/L,and those in control group were （4.38±0.84） mmol/L and （2.54± 0. 70） mmol/L. After treatment,TC and LDL-C in research group were （3.90±0. 73） retool/L,（2.04±0.62） mmol/L,and those in control group were （4.26± 0.72） mmol/L, （2.48 ± 0.65） mmol/L, and two groups showed statistical significance after treatment（ P 〈0.05）. Conclusion Low-fat diet can improve body mass, HbA1 c,TC and LDL-C of T2DM patients and curative effect is better than the conventional control group, and it is an effective way in the treatment of obese patients with T2DM.