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CD133在肿瘤临床检测中的研究进展 被引量：2

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摘要 研究认为，在恶性肿瘤中存在少部分具有“干细胞样”特性的细胞，它们具有自我更新、无限增殖及多向分化的潜能，是形成肿瘤细胞异质性和肿瘤细胞不断扩增的根源。CD133（又称Prominin-1）是一个含有5个跨膜区域的单链糖蛋白，研究表明其是多种肿瘤干细胞的表面标记。
作者 童文先 何安兵 刘爱华 王群 罗云秀
机构地区 武汉市第五医院肿瘤一科
出处 《中国医师进修杂志》 2012年第15期76-77,共2页 Chinese Journal of Postgraduates of Medicine
关键词 CD133 恶性肿瘤 临床检测 细胞异质性 单链糖蛋白 肿瘤干细胞 自我更新 多向分化
分类号 R730.4 [医药卫生—肿瘤]
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共引文献25

同被引文献19

  • 1Cai C,Yu JW,Wu JG,et al.CD133 promotes the invasion and metastasis of gastric cancer via epithelial-mesenchy- mal transition[J].Zhonghua Wei Chang Wai Ke Za Zhi,2013, 16(7) :662-667.
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  • 3Lee HH,Seo KJ,An CH,et al.CD133 expression is corre- lated with ehemoresistanee and early recurrence of gastric eancer[J].J Surg Oncol, 2012,106(8) :999-1004.
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  • 5Rappa G,Fodstad O,Lorico A.The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma [J].Stem Cells,2008,26 (12) : 3008-3017.
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  • 7Wakamatsu Y, Sakamoto N, Oo HZ, et al.Expression of can- cer stem cell markers ALDH1 ,CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer [J]. Pathol Int, 2012,62(2) : 112-119.
  • 8Ishigami S, Ueno S,Arigami T,et al.Prognostic impact of CD133 expression in gastric carcinoma[J].Anticancer Res, 2010,30(6) :2453-2457.
  • 9Chen S, Hou JH, Feng XY, et al. Clinicopathologic signifi- cance of putative stem cell marker,CD44 and CD133,in human gastric carcinoma [J],J Surg 0ncol,2013,107(8): 799-806.
  • 10唐毕锋,马立业,翟羽佳,余永伟,张敏峰,刘小康.肿瘤干细胞标志物CD133在胃癌中的表达及其临床意义[J].临床肿瘤学杂志,2008,13(6):495-498. 被引量：20

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中国医师进修杂志
2012年 第15期

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