多种血清肿瘤标志物联合检测对肺癌诊断的临床意义分析

Clinical Significance of Variety of Serum Tumor Markers in Detection of Lung Cancer

目的:探讨CA125、CYFRA21-1、CEA、NSE、AFP联合检测对肺癌的诊、诊断的敏感度以及特异性。方法:对我院收治的确诊为肺癌的患者选取120例作为A组,同期选择肺部良性病变患者61例作为B组,以及50例健康体检患者作为C组,将三组研究对象分别进行CA125、CYFRA21-1、CEA、NSE、AFP的检测。结果:A组患者CA125、CYFRA21-1、CEA、NSE、AFP的血清中含量明显高于B组以及C组(P<0.05);五种标记物联合检测的敏感度明显高于单一标志物的敏感度(P<0.05),但其特异性有明显的降低(P<0.05)。结论:采用CA125、CYFRA21-1、CEA、NSE、AFP联合检测,对肺癌的早期诊断以及治疗预后有较好的指导作用。

Objective： To explore the combined detection with CA125, CYFRA21-1, CEA, NSE, AFP for lung cancer diagnosis and their diagnostic sensitivity and specificity. Methods： 120 eases of patients diagnosed with lung cancer in our hospital were selected as the group A, and 61 cases of benign lung disease patients at the same period were selected as group B, and 50 healthy subjects as group C. Three groups of subjects were received respectively CA125, CYFRA21-1, CEA, NSE, AFP testing. Results： Patients in group A had significantly higher CA125, CYFRA21-1, CEA, NSE and AFP serum levels than patients in group B and group C （P 〈0.05）. Combination detection with five kinds of markers showed a significantly higher sensitivity than single marker detection （P〈0.05）, but a remarkable lower specificity （P〈0.05）. Conclusion： Combination detection with CA 125, CYFRA21-1, CEA, NSE, and AFP give a better guidance on early diagnosis of lung cancer and the treatment and prognosis.