软坚散结方对颈动脉粥样硬化治疗的临床观察

Clinical observation of the Ruanjian Sanjie recipe on treating AS

目的:观察软坚散结方对颈动脉粥样硬化(Atherosclerosis,AS)斑块的防治作用。方法:采用彩色多谱勒超声技术从高脂血症病人中检测出165例颈动脉内膜-中层(IMT)增厚与斑块形成的病人,随机分成心脉康组(55例)、血脂康组(55例)、西药组(55例),分别给予心脉康片、血脂康胶囊辛伐他汀6个月。比较治疗前后血清总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)及IMT与斑块消退的变化。结果:三组病人TC、LDL-C降低,HDL-C升高,颈动脉IMT与斑块均有消退,但以心脉康组更为显著(P<0.05),同时心脉康组HDL-C、TG降低。结论:软坚散结方可有效降低血脂,逆转颈动脉粥样硬化斑块。

Objective： To observe the effect of the Ruanjian Sanjie recipe on treating AS plaque prevention role.Methods： 165 patients with carotid atherosclerosis were randomly divided into 3 groups,The 1st group（n=55） received Xin Mai Kang tablet,the 2nd group received Xue Zhi Kang Capsule,and the 3rd group received Simvastatin.The treatment lasted 6 months.Results： After treatment,in all groups,carotid intima-media thickness（IMT） significantly thinned（P0.05）,plaque volume significantly reduced（P0.05）,serum levels of total cholesterol（TC）,triglyceride（TG）,low density lipoprotein cholesterol（LDL-C） significantly decreased（P0.05）,and high density lipoprotein cholesterol（HDL-C） significantly rised（P0.05）.The difference was most significant（P0.05） in Xue Zhi Kang group.Conclusion： Xin Mai Kang tablet can decrease blood lipid levels and alleviate carotid atherosclerosis as well.