血浆肿瘤坏死因子-α、白细胞介素-6与高血压性脑出血脑水肿的相关性研究

Analysis of relationship between plasma TNF-α, IL-6 levels and brain edema caused by hypertensive intrace- rebral hemorrhage

目的探讨急性高血压性脑出血患者血浆肿瘤坏死因子．仪（TNF。d）、白细胞介素_6（IL-6）的水平与脑水肿的相关性。方法对高血压性脑出血患者62例（观察组）和健康体检正常者50例（对照组）采用酶联免疫法（ELISA）定量法检测高血压脑出血组治疗前和治疗后1d、3d、7d、14d五个时间段和对照组血浆TNF-α、IL-6的表达，比较两组血浆中TNF-仅和IL-6含量；用CT测量高血压脑出血组水肿体积。分析高血压脑出血组血浆中IL-6、TNF-α的含量与血肿体积的相关性。结果观察组治疗前血浆TNF-α和IL-6含量分别为（15．62±9．49）μg／L、（67．47±6．31）ng／L，均高于对照组的（8．28±3．36）μg／L、（31．02±3．51）ng／L（t=9．17、64．28，均P=0．01）。经Spearman相关性分析显示，观察组TNF—α和IL-6水平与血肿周围体积均呈明显正相关（r=0．934，P=0。02；r=0．922，P=0．026）。结论血浆TNF—α、IL-6在高血压性脑出血后表达水平上调，TNF—α、IL-6可能参与了脑水肿的形成。

Objective To explore the relationship between plasma Tumor necrosis factor-alpha（ TNF-α）, Interleukin-6（IL-6） levels and brain edema caused by hypertensive intracerebral hemorrhage. Methods 62 patients with hypertensive intracerebral hemorrhage（ the observation group） and 50 healthy persons （the control group ） were selected. The expression of plasma TNF-α and IL-6 were determined by ELISA pre-therapy and 1 d,3d,7d, 14d after treatment in two groups ;The volume of cerebral edema was measured by CT. The relationship between plasma TNF-α, IL-6 levels and brain edema caused by hypertensive intracerebral hemorrhage were analyzed. Results Before treatment,the levels of TNF-α and IL-6 in the observation group were（ 15.62 ± 9.49）p,g/L and（67.47 ± 6. 31 ）ng/L, which were significantly higher than （8.28 ±3.36 ） μg/L and （ 31.02 ~ 3.51 ） ng/L of the control group （ t = 9.17, 64. 28, P = 0.01 ） , and Spearman analysis showed that the levels of TNF-α and IL-6 were positively correlated with the volume of cerebral edema（ r = 0. 934, P = O. 02 ; r = 0. 922, P = 0. 026 ）. Conclusion There was an up-regulation of TNF-α and IL-6 levels in the plasma of patients with hypertensive intraeerebral hemorrhage. TNF-α and IL-6 may promote the formation of cerebral edema during the course of hypertensive intracerebral hemorrhage.