全天麻胶囊对高血压患者脑血流的影响

The influence of Gastrodia elata capsule on cerebral blood flow in the treatment of patients with hypertension

目的观察全天麻胶囊对高血压患者脑血流的影响。方法将69例高血压患者随机分为治疗组36例和对照组33例，治疗组患者接受全天麻胶囊配合降压药治疗，对照组患者单用降压药治疗。两组患者治疗前及治疗后20d行经颅多普勒超声（TCD）检查，观察两组治疗前后颅内血管血流的变化。结果治疗组治愈12例、显效15例、有效8例、无效1例、总有效率97．2％，对照组分别为7例、12例、6例、8例、75．8％，两组临床疗效差异有统计学意义（Z=2．240，P〈0．05）。治疗20d后，对照组MCA、ACA、PCA、BA、VA平均流速与治疗前差异均无统计学意义（均P〉0．05）；治疗组MCA、ACA、PCA、BA、VA平均流速均低于对照组（t=-2．65、-2．44、-3．92、-3．31、-4．68，均P〈0．05）。结论全天麻胶囊配合降血压药较单用降压药治疗能显著改善高血压患者的疗效及脑血流状态。

Objective To observe the influence of Gastrodia elata capsule on cerebral blood flow in the treatment of patients with hypertension. Methods A total of 69 patients with hypertension were divided into the treatment group（ 36 cases） and the control group（ 33 cases）. The treatment group received treatment of Gastrodia elata capsule combined with antihypertensive drug, the control group received treatment of antihypertensive drug only. Two groups received TCD test before and 20 days after treatment, and the changes of blood flow of intracranial vessels before and after treatment were assessed. Results The total effective rate in treatment group was 97.2%, 12 cases cured, 15 cases of tangible effectiveness,8 cases of effectiveness, 1 case of invalidity. The total effective rate in control group was 75.8% ,7 cases cured, 12 cases of tangible effectiveness ,6 cases of effectiveness ,8 case of invalidity. The difference of clinical efficacy between the two groups was statistically significant （ Z = 2. 240, P 〈 0. 05 ）. The mean velocity of MCA, ACA, PCA, BA, VA of control group 20 days after treatment was not statistically different compared to those before treatment. The mean velocity of MCA, ACA, PCA, BA, VA of treatment group 20 days after treatment was lower than those before treatment（t= -2.65, -2.44, -3.92, -3.31, -4.68,all P〈0.05）.Conclusion The treatment of Gastrodia data capsule eonbined with antihypertensive drug can significantly improve curative effect of patients with hypertension and improve the condition of cerebral blood flow.