表皮生长因子受体及血管内皮生长因子在非小细胞肺癌组织中的表达

Expression and clinical significance of epidermal growth factor receptor and vascular endothelial growth fac- tor in non-small cell lung cancer

目的观察非小细胞肺癌（NSCLC）组织中表皮生长因子受体（EGFR）和血管内皮生长因子（VEGF）的表达情况以及与临床病理特征的关系。方法采用免疫组化法检测124例NSCLC组织和15例远离肿块无癌细胞浸润的肺组织（距肿瘤病变〉5cm）标本EGFR、VEGF的表达。结果EGFR、VEGF在124例NSCLC标本中的阳性表达率分别为52．4％、66．1％，在15例远离肿块无癌细胞浸润的肺组织（距肿瘤病变〉5cm）均无表达。Ⅲ期NSCLC组织的VEGF表达率为80．4％（41／51），高于Ⅰ～Ⅱ期的56．2％（41／73）（χ2=4．24，P〈0．05）；淋巴结阳性的NSCLC组织VEGF表达率为78．2％（50／64），明显高于淋巴结阴性的53．3％（32／60）（χ2=4．77，P〈0．05），VEGF和EGFR表达与病理类型、性别、年龄、肿瘤细胞分化等无关。EGFR与VEGF呈正相关关系（r=0．93，P〈0．05）。结论EGFR、VEGF在NSCLC组织中过表达；VEGF可能与TNM分期及淋巴结转移有关，EGFR与VEGF在NSCLC肿瘤血管形成过程中可能起协同作用。

Objective To observe the expression of epidermal growth factor receptor（EGFR） and vascular endothelial growth factor（VEGF） in non-small cell lung cancer（NSCLC） and the reletionship with clinic-pathologic parameters. Methods Immunohistochemistry of tissue sections was used to study the expression of EGFR and VEGF in 124 NSCLC tissues and 15 normal lung tissues adjacent to cancer tissues. Results The positive rates of EGFR and VEGF in 124 NSCLC samples were 52.4% ,66.1% ,while no expressed in the 15 normal lung tissues adjacent to cancer tissues. The positive rate of VEGF with stage III was higher than that with stage I - II （80.4% vs 56.2% ,P 〈 0.05 ）. The positive rate of VEGF with lymph node metastasis was higher than that without lymph node metastasis （78.2% vs 53.3% , P 〈 0.05 ）. The expression of VEGF and EGFR had no relationship with clinic pathological fac- tors including histological type of lung cancer, sex, age. EGFR and VEGF expression was statistically correlated with each other（r = 0.93,P 〈 0.05）. Conclusion EGFR and VEGF were overexpressed in NSCLC tissues. The expression of VEGF was correlated with TNM stages and lymph node metastasis. The expression of EGFR was correlated with VEGF expression in NSCLC tissues, which indicates they might act synergistically in angiogenesis of NSCLC.