斑蝥酸钠维生素B6在乳腺癌辅助化疗中的应用

Application and curative effect of Aiyishu injection in neoadjuvant chemotherapy of breast cancer

目的评价斑蝥酸钠维生素B6注射液（艾易舒注射液）对乳腺癌术前辅助化疗的作用。方法70例乳腺癌患者随机分为两组，治疗组36例，应用艾易舒合并CTF化疗；对照组34例，单用化疗，比较两组抗肿瘤疗效、临床症状变化、细胞免疫功能、化疗不良反应及生活质量的变化。结果治疗组患者CD3、CD4、CD8水平和CD4／CD8比值及NK细胞活性高于对照组（P〈0．05）；治疗组抗肿瘤有效率为41．67％，对照组抗肿瘤有效率为36．67％；治疗组患者白细胞减少（33．33％）和消化道反应（38．89％）发生率明显小于对照组（P〈0．05），其他毒副反应差异无统计学意义（P〉0．05）；治疗组患者KPS提高幅度36．11％（13／36）高于对照组11．76％（4／34）（P〈0．05）。结论艾易舒注射液可作为乳腺癌患者术前化疗的辅助用药，能增强化疗疗效，提高免疫能力，减轻化疗的不良反应。

Objective To investigate the synergetic effect of Aiyishu injection in combination with neoadju- vant chemotherapy in the treatment patients with breast cancer. Methods Seventy patients with breast carcinoma at stage Ⅰ-Ⅲwere randomly divided into treatment group （Aiyishu associated CAF regimen） （n = 36） and control group （ CAF regimen） （ n = 34）. The activities of T cells and NK cells, response rate, change of clinical symptoms, ad- verse effects and living quality were evaluated in patients of two groups. Results The levels of CD3 , CD4, CD8 and the ratio of CD4/CD8 and the activity of NK cells in treatment group were higher than those in control group （ P 〈 0. 05 ） ; the response rate was 41.67% and 36.67% in group 1 and 2 respectively, but had no significant difference ; the incidence rates of leucopenia and gastrointestinal disturbance were 33.33% and 38.89% respectively in patients of treatment group, whereas the rates were 67.65% and 67.65 % , in control group （P 〈 0.05 ）. In treatment group, KPS increased in 36. 11% （13/36） patients, and it was higher than that in control group（ 11.76% ,4/34） （P 〈0. 05 ）. Conclusion Aiyishu injection can increase the ability of immunity of body and reduce the toxic and adverse reaction, and improve the living quality in patients with breast cancer when it is used in pre-operative chemotherapy of breast cancer.