奥洛他定治疗过敏性结膜炎临床观察

Clinical observation of olopatadine in the treatment of allergic conjunctivitis

目的观察奥洛他定治疗过敏性结膜炎的临床治疗效果。方法将67例过敏性结膜炎患者，随机分为观察组（34例）和对照组（33例）。观察组给予0．1％盐酸奥洛他定滴眼液，每眼1滴／次，2次／d，早晚各1次，眼用；对照组给予2％色甘酸钠滴眼液，每眼1滴／次，4次／d，眼用。均治疗7d。观察两组治疗后1h、7d、30d的症状改变情况及不良反应的发生情况。结果观察组治疗7d后各症状的总有效率分别为91．18％、91．18％和85．19％，均优于对照组的72．7％、75．76％、85．19％（均P〈0．05）。结论奥洛他定用于治疗过敏性结膜炎起效快、作用时间长、安全性高，值得临床推广使用。

Objective To observe the effect of olopatadine in the treatment of allergic conjunctivitis. Methods 67 cases with allergic conjunctivitis were randomly divided into 2 groups. The observation group was given 0.1% hydroehloride olopatadine eyedrop twice a day for 7 days, while the control group was given 2% cromolyn sodi- um 4 times a day for 7 days. One hour,7 days ,20 days after treatment, the changes of symptoms and the incidence of adverse reactions were observed. Results 7 days after treatment, the total effective rate of the observation group in treatment of eye itching,conjunetival hyperemia and eonjunctiva nipple were 91.18% ,91.18% and 85.19% , better than that of the control group [ 72.7% ,75.76% ,85.19% （ all P 〈 0.05 ） ]. Conclusion It＇s rapid onset long dura- tion of action and high security that olopatadine in the treatment of allergic conjunctivitis, and it was worthy to promote to be used in clinic.