丹红注射液治疗不稳定型心绞痛的疗效及对内皮功能的影响

The clinical effect of Danhong injection in treatmant unstable angina and its effect on the endothelial function

目的探讨丹红注射液治疗不稳定型心绞痛的临床疗效及对血管内皮功能的影响。方法选取100例不稳定型心绞痛患者，随机分为对照组和治疗组，每组50例。所有患者住院后均进行常规治疗，对照组在常规治疗的基础上静脉滴注单硝酸异山梨酯25mg＋5％葡萄糖溶液500ml或0．9％氯化钠注射液500ml；治疗组另外给予丹红注射液40ml＋5％葡萄糖溶液或0．9％氯化钠注射液500ml。观察两组一氧化氮（NO）、内皮素（ET）、C反应蛋白（CRP）水平变化。结果治疗后治疗组患者心绞痛、心电图疗效均明显优于对照组（均P〈0．05）；治疗后两组患者的NO水平均明显高于治疗前，ET、CRP水平则均低于治疗前（P〈0．05）；且治疗组患者NO水平高于对照组，ET、CRP水平均低于对照组（均P〈0．05）。结论采用丹红注射液治疗不稳定型心绞痛，可有效缓解心绞痛的发作并能显著改善其内皮功能。

Objective To investigate the clinical effect of Danhong injection to treat unstable angina and its effect on the endothelial function. Methods 100 cases with unstable angina were randomly divided into control group and treatment group, each group had 50 cases. All patients were hospitalized for routine treatment, the control group was given lsosorbide mononitrate and 5% glucose solution or saline ,while the treatment group was given Danhong in- jection and 5% glucose solution or saline on the basis of the routine treatment. Results After treatment,the efficacy of ECG and angina in the treatment group were better than the control group （ all P 〈 0.05 ） ; the NO level of post-treat- ment was higher than pre-treatment, ET and CRP levels were lower than pre-treatment（ all P 〈 0.05 ） ;the NO level in the treatment group was higher than the control group, the ET and CRP levels were lower than the control group （all P 〈 0.05 ）. Conclusion Danhong injection for the treatment of patients with unstable angina could effectively relieve the angina and improve the endothelial function.