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钙调神经磷酸酶／活化T细胞核因子信号通路在骨代谢中的作用 被引量：1

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摘要 骨是一种不断更新的组织，骨形成和骨吸收的动态平衡维持着正常的骨代谢。在骨重建过程中，由成骨细胞引起的骨形成与破骨细胞引起的骨吸收之间的偶联，是维持骨结构完整性及合适骨强度的关键。参与骨形成的信号通路主要有骨形成蛋白（BMPs）途径、MAPKs途径、Smads途径。大量研究证实，OPG—RANK—RANKL调节轴是影响破骨细胞分化、发育、调节其功能的唯一终途径。目前发现破骨细胞内与RANK相关的信号转导通路主要有4条，即NF—κB通路，MAPK通路，P13K／Akt通路和CaN／NFAT通路。
作者 谢莹 于燕妮
机构地区 贵阳医学院病理学教研室
出处 《中国基层医药》 CAS 2012年第9期1412-1414,共3页 Chinese Journal of Primary Medicine and Pharmacy
基金 科学技术部国际合作项目
关键词 信号通路 活化T细胞核因子 钙调神经磷酸酶 骨代谢 骨形成蛋白 破骨细胞分化 RANKL MAPKs途径
分类号 R363 [医药卫生—病理学]
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  • 2贾辅忠.肝病与肠道微生态环境[J].中国实用内科杂志,2006,26(7):971-974. 被引量：28
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中国基层医药
2012年 第9期

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