主动脉夹层发病机制的分子生物学研究进展

Research Progress on Molecular Biology of Pathogenesis of Aortic Dissection

主动脉夹层(AD)是一种高病死率及高致残率的急性大血管疾病。发病因素包括遗传性疾病、动脉壁的病理改变、基质金属蛋白酶的改变、高血压及免疫炎性疾病等,但发病机制尚不完全清楚。随着分子生物学技术的发展,开始从基因及蛋白质水平探索AD的发病机制,并取得一些进展。现就主动脉夹层发病机制的分子生物学研究进展予以综述。

Aortic dissection（AD） is an acute macrovascular disease of high mortality and high morbidi- ty. The risk factors include genetic disease, pathological changes of the arterial wall, matrix metalloproteinases change, hypertension and immune inflammatory disease etc. , however, the pathogenesis is still not completely clear. Along with the development of molecular biotechnology, exploration for the pathogenesis from gene and protein level has started and has made some progress, and here is to make a review on the research progress.