摘要
原发性胆汁性肝硬化(PBC)是一种原因不明的慢性进展性胆汁淤积性肝病。临床上可以表现为无临床症状,也可以表现为肝硬化。诊断PBC依赖于反映胆汁淤积的生化指标、抗线粒体抗体阳性和非化脓性胆管炎的组织学改变。熊去氧胆酸被认为是能改善PBC预后的有效药物,然而,仍有1/3的患者用熊去氧胆酸后未达到满意效果而做肝移植治疗。因此,需要早期诊断PBC和发明新的药物来解决这一问题。
Primary biliary cirrhosis （ PBC ） is a chronic and progressive cholestatic disease of the liver with unknown etiology. The presentation of PBC is various from asymptomatic to overt cirrhosis. The diagnosis of PBC is based on cholestatic biochemical liver tests, presence of antimitochondrial antibody and histologic changes of nonsuppurative destructive cholangitis. Ursodeoxycholic acid （UDCA）is the widely approved ther- apy which can improve the prognosis of patients with PBC. However, 1/3 of patients does not respond to UD- CA therapy and may require liver transplantation. So every effort to diagnose PBC in earlier stage and to de- velon new theraneutic dru^s should be made.
出处
《医学综述》
2012年第10期1515-1517,共3页
Medical Recapitulate
关键词
原发性胆汁性肝硬化
临床表现
诊断
治疗
Primary biliary cirrhosis
Clinical manifestation
Diagnosis
Therapy
