消化性溃疡的治疗靶点

Therapeutic Targets of Peptic Ulcer

消化性溃疡通常发生在胃和十二指肠球部。消化性溃疡的发生是因胃黏膜的侵袭因素(胃酸、胃蛋白酶、幽门螺杆菌感染、非甾体类抗炎药等)与防御因素(黏液、黏膜屏障、黏膜血流量、前列腺素和表皮生长因子等)间的失衡而引起的。通过对消化性溃疡的治疗靶点进行分析总结,有助于指导其治疗用药及防止复发,同时也有利于研发新的治疗溃疡药物。

Peptic ulcer usually occurs in the stomach and proximal duodenum when a disturbance in the balance between the defensive （ mucus, mucosal harrier, mucosal blood flow, prostaglandin, and epi- dermal growth factor, etc. ） and aggressive factors （ gastric acid, pepsin, Helieobacter pylori infection, non- steroidal anti-inflammatory drugs, etc. ） on the gastric and duodenal bulb muoosae happens. It can help to choose a suitable treatment and prevention from recurrence and also contributes to the design of new ther- apeutic drugs for ulcers through the summary of the mechanism and therapeutic targets of peptic ulcer.