恶性肿瘤患者血清同型半胱氨酸的变化

Changes of serum homocysteine in patients with malignant tumor

目的:探讨血清同型半胱氨酸在恶性肿瘤患者的临床价值。方法:选取本院住院治疗恶性肿瘤患者空腹血清标本,用日本Olympus AU 2700自动生化分析仪检测血清同型半胱氨酸水平。结果:血清同型半胱氨酸含量在男女性间差别具统计学意义(P<0.01),男性高于女性,年龄段间也存在一定的差异。乳腺癌组同型半胱氨酸含量与女性对照组间差别无统计学意义(P>0.05),其他各组与对照组比较,除胃癌组P>0.05,结直肠癌组0.01<P<0.05外,其余各组均P<0.01。结论:血清同型半胱氨酸在肺癌、肝癌、结直肠癌患者中升高,其可作为患者病情诊断、疗效观察、预后判断的一参考指标。

Objective：To explore the clinical value of serum homocysteine in patients with malignant tumor.Methods： Fasting serum samples from patients with malignant tumor in our hospital were selected for detection of serum homocysteine by Olympus AU 2700 analyzer.Results： The difference of serum homocysteine content between male and female had statistical significance（P〈0.01）,higher in males than that in females,certain difference was also found among different ages.The difference of serum homocysteine levels between breast cancer group and control group had no statistical significance（P〈0.05）.In comparison of control group and other groups,gastric cancer group was found P〈0.05,colorectal cancer was found 0.01P〈0.05,while other groups were all P〈0.01.Conclusion： Increase of homocysteine level in patients with lung cancer,liver cancer or colorectal cancer can be a reference indicator in diagnosis,curative effect observation and prognosis of the diseases.