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老年2型糖尿病并发非酒精性脂肪肝与颈动脉粥样硬化的关系 被引量:1

Relationship between aged type 2 diabetes complicating nonalcoholic fatty liver and carotid artery atherosclerosis
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摘要 目的探讨老年2型糖尿病(T2DM)患者并发非酒精性脂肪肝(NAFLD)与颈动脉粥样硬化的关系。方法将150例老年T2DM患者分为合并NAFLD 76例(T2DM+NAFLD组)与未合并NAFLD 74例(T2DM组),比较两组各项生物化学指标、颈动脉内膜中层厚度(CIMT),观察斑块形成和动脉狭窄情况。结果老年T2DM+NAFLD组体质量指数(BMI)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、三酰甘油(TG)、空腹胰岛素(FINS)、空腹C肽(FCP)、餐后2h C肽(2hCP)、胰岛素抵抗指数(HOMA-IR)、CIMT明显高于老年T2DM组(P<0.05)。老年T2DM+NAFLD组高密度脂蛋白(HDL)低于老年T2DM组(P<0.05)。老年T2DM+NAFLD组颈动脉粥样硬化患病率、斑块形成率、动脉狭窄率均高于老年T2DM组(P<0.05)。CIMT与糖尿病病程、年龄、TG、总胆固醇(TC)、空腹血糖(FPG)、餐后2h血糖(2hPG)、FINS、餐后2h胰岛素(2hINS)相关。结论老年T2DM并发NAFLD与血脂代谢紊乱、胰岛素抵抗有关,且易于发生颈动脉粥样硬化。 Objective To investigate the relationship between aged type 2 diabetes mellitus(T2DM) complicating nonalcoholic fatty liver disease(NAFLD) and carotid artery atherosclerosis.Methods 150 cases of aged T2DM were divided into the DM + NAFLD group(76 cases) and the DM group(74 cases) without NAFLD.The biochemical parameters and carotid intima-media thickness(CIMT) were compared between the two groups.Their atherosclerotic plaque and arterial stenosis were observed.Results The level of BMI,ALT,AST,TG,FINS,FCP,2hCP,HOMA-IR and CIMT in the DM+NAFLD group were higher than those in the DM group(P0.05).The level of HDL in the DM+NAFLD group was lower than that in the DM group(P0.05).The incidence rate of carotid artery atherosclerosis,formation rate of atherosclerotic plaque and arterial stenosis rate in the DM+NAFLD were higher than those in the DM group(P0.05).CIMT was correlated with the DM duration,age,TG,TC,fasting-plasma glucose(FPG),2-h postprandial glucose(2hPG),FINS,2-h postprandial insulin(2hINS).Conclusion Aged T2DM complicating NAFLD is related with dyslipidemia and insulin resistance,and easy to occur carotid artery atherosclerosis.
出处 《现代医药卫生》 2012年第10期1469-1470,共2页 Journal of Modern Medicine & Health
关键词 动脉硬化 颈动脉 糖尿病 2型 脂肪肝 Arteriosclerosis Carotid arteries Diabetes mellitus type 2 Fatty liver
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  • 1Fatty Liver and Alcoholic Liver Disease Study Group of the Chinese Liver Disease Association..非酒精性脂肪性肝病诊疗指南[J].中华肝脏病杂志,2006,14(3):161-163. 被引量:1515
  • 2Williams CD,Stengel J,Asike MI, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middleaged population utilizing ultrasound and liver biopsy :a prospective study[J]. Gastroenterology, 2011,140 ( 1 ) : 124-131.
  • 3Okanoue T,Umemura A ,Yasui K,et al. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in Japan[J]. J Gastroenterol Hepatol, 2011, 26(1 ) : 153-162.
  • 4Kagansky N, Levy S,Keter D,et al. Non-alcoholic fatty liver diseasea com- mon and benign finding in octogenarian patients[J]. Liver Int ,2004,24(6) : 588-594.
  • 5Sookoian S, Pirola CJ. Non-alcoholic fatty liver disease is strongly associ- ated with carotid atherosclerosis : a systematic review[J]. J Hepatol, 2008, 49 (4) : 600-607.
  • 6Petit JM, Guiu B,Terriat B, et al. Nonalcoholic fatty liver is not associat- ed with carotid intima-media thickness in type 2 diabeticpatients[J]. J Clin Endocrinol Metab,2009,94(10) :4103-4106.
  • 7Poanta LI,Albu A, Fodor D. Association between fatty liver disease and carotid atherosclerosis in patients with uncomplicated type 2 diabetes mellitus[J]. Med Uhrason, 2011,13 (3) : 215-219.
  • 8林爱萍,于健,祖颖,欧阳清,杨蓥境,苏珂,龙艳.2型糖尿病合并非酒精性脂肪肝患者动脉硬化危险因素的分析[J].中华老年心脑血管病杂志,2011,13(5):404-406. 被引量:17
  • 9DeFronzo RA. Insulin resistance,lipotoxicity, type 2 diabetes and atheros- clerosis :the missing links. The Claude Bernard Lecture 2009[J]. Diabeto- logia,2010,53 (7) : 1270-1287.

二级参考文献27

  • 1胡国平,刘凯,赵连三.多烯磷脂酰胆碱(易善复)治疗酒精性肝病和脂肪肝的系统评价[J].肝脏,2005,10(1):5-7. 被引量:108
  • 2卢曙芳,沈建国,朱麒钱,官莉莉.2型糖尿病患者颈动脉内膜中层厚度与细胞间黏附分子1、C反应蛋白的相关性[J].中华内分泌代谢杂志,2006,22(4):358-359. 被引量:20
  • 3Targher G,Arcaro G.Non-alcoholic fatty liver disease and increased risk of cardiovascular disease.Atherosclerosis,2007,191:235-240.
  • 4Yoneda M,Mawatari H,Fujita K,et al.High sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis(NASH)and also of the severity of fibrosis in NASH.J Gastroentero1,2007,42:573-582.
  • 5Cheng AY,Kong AP,Wong VW,et al.Chronic hepatitis B viral infection independently predicts renal outcome in type 2 diabetic patients.Diabetologia,2006,49:1777-1784.
  • 6Schwimmer JB,Behling C,Newbury R,et al.Histopathology of pediatric nonalcoholic fatty liver disease.Hepatology,2005,42:641-649.
  • 7Neuschwander Tetri BA,Caldwell SH.Nonalcoholic steatohepatitis:summary of an AASLD Single Topic Conference.Hepatology,2003,37:1202-1219.
  • 8Angulo P.Nonalcoholic fatty liver disease.N Engl J Med,2002,346:1221-1231.
  • 9Ghali P,Lindor KD.Hepatotoxicity of drugs used for treatment of obesity and its comorbidities.Semin Liver Dis,2004,24:389-397.
  • 10Harrison SA,Torgerson S,Hayashi P,et al.Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis.Am J Gastroenterol,2003,98:2485-2490.

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