摘要
以甲基丙烯酸（MAA）、甲基丙烯酸甲酯（MMA）和丙烯酸丁酯（BA）为聚合单体，通过乳液聚合方式，合成了具有内增塑性能的肠溶型丙烯酸树脂。考察了原料配比、引发剂用量、乳化剂用量、反应温度、分子量调节剂、加料方式对乳液稳定性及膜性能的影响。用红外光谱对聚合物分子结构进行了表征，用DSC测试了聚合物的热稳定性，用黏度法测定了聚合物的相对分子质量，并且测试了膜在不同pH值溶液中的失重率，并且对包衣片崩解性能进行初步实验。结果表明，聚合物的热稳定性较好，相对分子质量在15—20万之间，膜在碱性条件下失重率较大，而在酸性条件下失重率较小，符合药典要求。
Enteric acrylic resin with internal plasticity was prepared by emulsion polymerization with using methylacrylic acid, methyl methacrylate and butyl acrylate as monomer. The influence factors on emulsion stability and membrane performance such as ratio of raw materials, emulsifier, initiator, temperature, molecular weight regulator and the way of feeding were investigated. The structure of polymer was characterized by IR spectrum, the thermal stability was tested by DSC, the polymer molecular weight was measured through viscosity method, the weightlessness rate of film in solutions with different pH values were also determined, and the properties of the coating disintegration were tested preliminarily. The results showed that the thermal stability of polymer was good, its molecular weight was in the range of 150000 to 200000, the weightlessness rate of film was great in alkaline conditions, and it was small in acidic conditions. These properties could meet the pharmacopeia requirements
出处
《化学与粘合》
CAS
2012年第3期33-36,共4页
Chemistry and Adhesion
关键词
丙烯酸树脂
乳液聚合
包衣
Acrylic resin
emulsion polymerization
coating
