胸腔积液中的中性粒细胞活化肽-78、生长相关性肿瘤基因-α和白细胞介素-8水平变化的意义

STUDY ON THE LEVEL OF EPITHELIAL NEUTROPHIL-ACTIVATING PEPTIDE-78,GROWTH-REGULATED ONCO-GENE-αAND INTERLEUKIN-8 IN PLEURAL EFFUSION

目的探讨结核性和恶性胸腔积液中的中性粒细胞活化肽-78、生长相关性肿瘤基因-α和白细胞介素-8的临床变化意义。方法选择2007年7月-2011年8月在本院住院的78例患者渗出性胸腔积液,包含40例结核性胸腔积液和38例恶性胸腔积液。应用酶联免疫吸附测定(enzyme linked immunosorbent assay,ELISA)法测定胸腔积液中的中性粒细胞活化肽-78、生长相关性肿瘤基因-α和白细胞介素-8水平。结果与结核性胸腔积液相比,恶性胸腔积液中的中性粒细胞活化肽-78、生长相关性肿瘤基因-α和白细胞介素-8均显著增高(P<0.05)。结论联合检测胸腔积液中的中性粒细胞活化肽-78、生长相关性肿瘤基因-α和白细胞介素-8水平对鉴别结核性和恶性胸腔积液具有临床诊断价值。

Objective To study the clinical significance of epithelial exudative pleural effusion neutrophil - activating peptide - 78, growth - regulated onco - gene - ct and interleukin - 8 （ IL - 8 ） in tuberculous and malignant pleural effusion. Methods From July 2007 to August 2011,78 cases with exudative pleural effusion including 40 patients with tuberculous pleural effusion and 38 patients with malignant pleural effusion were enrolled. Epithelial neutrophil - activating peptide - 78, growth - regulated onco- gene - a and IL - 8 of all patients were measured by enzyme linked immunosorbent assay （ELISA）. Results Compared with tuberculous pleural effusion group, epithelial neutrophil- activating peptide - 78, growth - regulated onco - gene - ct and IL - 8 were significantly higher in malignant pleural effusion group （ P 〈 0.05 ）. Conclusion The combined detection of epithelial neutrophil - activating peptide -78, growth -regulated onco -gene -oL and IL- 8 levels in pleural fluid has diagnostic value in differentiating tuberculous and malignant pleural effusion.