常德市甲型H1N1流感感染状况血清学调查

Serology investigation of influenza A(H1N1) infection in Changde City

目的掌握常德市不同时期、不同地区、不同人群甲型H1N1流感动态,为制定防控措施提供科学依据。方法采用多阶段分层随机抽样,共抽取225人进行血清学调查。结果 2010年1月、4月、8月共采集血清标本675份,血清抗体滴度阳性为208份,阳性率为30.81%,三次血清抗体阳性率比较差异无统计学意义(χ2=0.72,P>0.05)。三次调查城市人群抗体阳性率均高于农村;各年龄组抗体阳性率不同,第一次调查6岁～组阳性率最高位46.81%,第二、三次调查,均为16岁～组最高,分别为57.78%、40.00%,60岁以上人群每次调查感染率均较低。接种过季节性流感疫苗及甲型H1N1流感疫苗的人群其甲流抗体阳性率均高于未接种人群。结论常德市2010年甲流病毒未发生变异,人群在一定程度上建立了甲型H1N1流感的免疫屏障,能有效遏制甲型H1N1流感爆发流行。

Objective To master the dynamic trend of H1N1 among different population from different regions in Changde City during the different periods and provide scientific basis for formulating prevention and control measures.Methods 675 copies of serum specimens from 225 people were collected using multistage stratified random sampling.Results 675 copies of serum specimens were collected in January,April,August of 2010,208 copies of positive serum antibody titer were found with the positive rate of 30.81%.There＇s not statistically significant difference（χ2=0.72,P0.05）of the serum antibody positive rate during three different surveys.Positive rate among urban population was higher than in rural area.Different antibody positive rates were found among different age groups,i.e.the highest positive rate（46.81%）were found in group aged 6 years old during the first survey,however,the group aged 16 had the highest positive rates during the second（57.78%）and third survey（40.00%）,respectively.The infection rate among group aged over 60 years was relatively lower in each survey.The vaccinated population against seasonal influenza and H1N1 influenza had higher positive rate than the unvaccinated population.Conclusion H1N1 virus hasn＇t been mutated in Changde City in 2010.influenza H1N1 immune barrier has been established,which can effectively restrain the outbreak of H1N1.