脑室出血早产儿血浆MMP-2和MMP-9测定的临床意义

Significance of detection of plasma MMP-2 and MMP-9 in diagnosis of the periventricular hemorrhage-intraventricular hemorrhage premature infants

目的探讨血浆基质金属蛋白酶-2和9(MMP-2、MMP-9)在早产儿脑室周围-脑室内出血(PVH-IVH)时的临床意义。方法采用ELISA法测定早产儿脑室周围-脑室内出血患儿及20例对照组早产儿(无颅内出血等并发症)血浆MMP-2、MMP-9含量。结果 PVH-IVH患儿MMP-2、MMP-9比对照组早产儿显著升高(均P<0.01),随着出血程度加重,血浆MMP-2、MMP-9均明显升高(均P<0.01)。结论血浆MMP-2和MMP-9含量的变化,可客观早期的判断PVH-IVH的发生、损伤程度。

Objective To investigate the clinical significance of detection of plasma MMP-2 and MMP-9 in dangosis of the periventricular hemorrhage-intraventricular hemorrhage（PVH-IVH） premature infants.Methods ELISA method was to determine the contents of MMP-2 and MMP-9 in blood plasma of 40 premature infants and 20 controls premature infants without the complication of intracranial hemorrhage,etc.Results The contents of MMP-2 and MMP-9 in premature infants with PVH-IVH was significantly higher than those of the control group（P0.01）and the contents of MMP-2 and MMP-9 increaed obviously with the bleeding degree aggravation.Conclusion The change of contents of MMP-2 and MMP-9 in blood plasma disclose tge early occurrence and injury extent of PVH-IVH.