摘要
目的评价国产重组酵母乙肝疫苗(YDV)的免疫效果。方法电子检索MEDLINE、《中国期刊全文数据库》(CNKI)和万方全文数据库等数据库,运用RevMan 4.2.8软件对YDV免疫效果的研究进行Meta分析。结果共纳入6篇文献。5ugYDV免疫后5~10年与免疫后1年的乙肝表面抗原(HBsAg)阳性率的OR值为0.96,其95%可信区间为(0.46,1.99);乙肝核心抗体(抗-HBc)阳性率的OR值为1.10,其95%可信区间为(0.69,1.75),免疫后5~10年与免疫后1年的HBsAg阳性率和抗-HBc阳性率无显著差别。结论乙肝疫苗在5~10年内的免疫效果良好,不须开展加强免疫。
Objective To evaluate immune efficacy of domestic recombinant yeast-derived hepatitis B vaccine(YDV)by literature review.Methods The data relevant to the immune efficacy of domestic recombinant yeast-derived hepatitis B vaccine on MEDLINE,EMBASE,CNKI were retrieved and anlayzed with Meta-analysis with assistance of RevMan 4.2.8.Results A total of 6 studies were included into the review.The OR of HBsAg positive rate in subjects a year after immunization vs those 50~10 years after imunization with dose of 5ug of YDV was 0.96(0.46,1.99)(95%CI).The OR of Anti-HBc was 1.10(0.69,1.75)(95%CI) in 5~10 years VS 1 year.There was no significant difference in HBsAg and Anti-HBc.Conclusion YDV has good immune efficacy in 5~10 years.IT is not necessary to carry on boost immunization.
出处
《中国热带医学》
CAS
2012年第4期501-503,共3页
China Tropical Medicine
基金
福建省卫生厅青年科研课题(No.2008-2-9)
关键词
重组酵母乙肝疫苗
免疫效果
META分析
Recombinant hepatitis B vaccine in yeast(YDV)
Immune efficacy
Meta analysis