国产重组酵母乙肝疫苗免疫效果的Meta分析

Meta analysis of immune efficacy of domestic recombinant yeast-derived hepatitis B vaccine

目的评价国产重组酵母乙肝疫苗(YDV)的免疫效果。方法电子检索MEDLINE、《中国期刊全文数据库》(CNKI)和万方全文数据库等数据库,运用RevMan 4.2.8软件对YDV免疫效果的研究进行Meta分析。结果共纳入6篇文献。5ugYDV免疫后5～10年与免疫后1年的乙肝表面抗原(HBsAg)阳性率的OR值为0.96,其95%可信区间为(0.46,1.99);乙肝核心抗体(抗-HBc)阳性率的OR值为1.10,其95%可信区间为(0.69,1.75),免疫后5～10年与免疫后1年的HBsAg阳性率和抗-HBc阳性率无显著差别。结论乙肝疫苗在5～10年内的免疫效果良好,不须开展加强免疫。

Objective To evaluate immune efficacy of domestic recombinant yeast-derived hepatitis B vaccine（YDV）by literature review.Methods The data relevant to the immune efficacy of domestic recombinant yeast-derived hepatitis B vaccine on MEDLINE,EMBASE,CNKI were retrieved and anlayzed with Meta-analysis with assistance of RevMan 4.2.8.Results A total of 6 studies were included into the review.The OR of HBsAg positive rate in subjects a year after immunization vs those 50~10 years after imunization with dose of 5ug of YDV was 0.96（0.46,1.99）（95%CI）.The OR of Anti-HBc was 1.10（0.69,1.75）（95%CI） in 5~10 years VS 1 year.There was no significant difference in HBsAg and Anti-HBc.Conclusion YDV has good immune efficacy in 5~10 years.IT is not necessary to carry on boost immunization.