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右美托咪定与心跳骤停 被引量：6

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摘要 右美托咪定是α2受体激动剂,作用于中枢及外周突触前/后α2受体,具有复杂的心血管效应.心动过缓、低血压是其常见的不良作用,严重者发生窦性停搏,通过输入液体给予阿托品可以纠正,但时间短暂,停用右美托咪定或经处理后（阿托品、心脏按压）可缓解.右美托咪定很少导致严重的左心室功能障碍和心源性休克,但有引起心跳骤停的报道.本文查阅到8篇与右美托咪定有关的心跳停搏/骤停文献,另有1篇未列入讨论[1],因作者认为心跳骤停与血管紧张素转换酶抑制剂有直接关系,而编辑则将其归因于丙泊酚与右美托咪定对心脏的协同抑制作用[2].
作者 任建军 董振明
机构地区 河北医科大学第二医院麻醉科
出处 《河北医科大学学报》 CAS 2012年第4期489-494,共6页 Journal of Hebei Medical University
关键词 心脏停搏 右美托咪定 综述文献
分类号 R541.78 [医药卫生—心血管疾病]
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参考文献25

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同被引文献74

  • 1邵新峰,邢玉英.右美托咪定在临床麻醉中应用的研究现状[J].中华临床医师杂志（电子版）,2012,6(18):136-138. 被引量：24
  • 2董兆,孙建宁.眼科手术与眼心反射[J].东南大学学报（医学版）,2007,26(2):148-151. 被引量：24
  • 3ABDELMALAK B, MAKARY L, HOBAN J, et al. Dexmedetomidine as sole sedative for awake intubation in management of the critical airway [ J ]. J Clin Anesth, 2007,19 (5) :370 -373.
  • 4DUTYA S, KAROL MD, COHEN T, et al. Effect of dexmedetomidine on propofol requirements in healthy subjects [J]. J Pharm Sei ,2001,90(2) :172 -181.
  • 5YILDIZ M, TAVLAN A, TUNCER S, et al. Effect of dexmedetomidine on haemodynamic responses to laryngoscopy and intubation : perioperative haemodynamics and anaesthetic requirements[ J]. Drugs R D ,2006,7( 1 ) :43 -52.
  • 6POTYS AL, ANDERSON BJ, HOLFORD NH, et al. Dexmedetomidine hemodynamics in children after cardiac surgery [J]. Paediatr anaesth,2010,20(5) : 425 -433.
  • 7QIAO H, SANDERS RD, MA D, et al. Sedation improves early outcome in severely septic Sprague Dawley rats[ J]. Criti Care, 2009,13(4) :R136.
  • 8MAURTUA MA, CATA JP, MARTIRENA M, et al. Dexmedetomidine for deep brain stimulator placement in a child with primary generalized dystonia: case report and literature review [ J ]. J Clin Anesth ,2009,21 ( 3 ) :213 - 216.
  • 9MANTZ J, JOSSERAND J,HAMADA S. Dexmedetomidine : new insights [ J ]. Eur J Anaesthesiol,2011,28 ( 1 ) : 3 - 6.
  • 10ROZET I, MUANGMAN S, VAVILALA MS, et al. Clinical experience with dexmedetomidine for implantation of deep brain stimulators in Parkinson 's disease [ J ]. Anesth Analg, 2006,103 (5) :1224 - 1228.

引证文献6

二级引证文献47

河北医科大学学报
2012年 第4期

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