摘要
本文应用HPLC 法测定血浆中扑热息痛的浓度,比较了速效伤风片、速效伤风粉药胶囊、颗粒囊胶中扑热息痛的生物利用度,并计算动力学参数。实验表明,扑热息痛在兔体内药动学符合二室开放式模型。不同剂型的速效伤风制剂动力学参数有较大差别,颗粒胶囊的绝对生物利用度为43.60%,高于其它制剂.
The plasma concentration of paracetamol in different“Su Xiao Shang Feng”preparatians was determined by HPLC.Bioavailability and pharmacokinetics ofparacetamol in“Sn Xiao Shang Feng”tablet、powder capsnle and granule cap-sule were measured and compared.The results showed that the rabbit drug con-centration-time curve have two compartmental characteristics,the absolute bio-availability of granule capsnle was 43.6% which higher than the other two
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1990年第5期195-197,共3页
Chinese Journal of Hospital Pharmacy
关键词
速效伤风制剂
生物利用度
色谱法
“Su Xiao Shang Feng”Jiao Nang(Pian)
paracetamol
bioavailability
