摘要
[目的]探讨培美曲塞联合顺铂治疗晚期非小细胞肺癌的疗效和毒副反应。[方法]应用培美曲塞500 mg/m2联合顺铂75 mg/m2方案治疗34例晚期非小细胞肺癌患者。[结果]总有效率达38.2%,其中初治组有效率为43.7%,复治组有效率为33.3%。主要毒副反应为骨髓抑制、恶心呕吐、便秘及口腔黏膜炎等。[结论]培美曲塞联合顺铂治疗晚期非小细胞肺癌有较好疗效,毒副反应可耐受。
[ Objective] To evaluate the efficacy and side -effect of pemetrexed combined of cisplatin in the treat of non - small cell lung cancer. [ Methods ] A total of 34 cases of advanced non - small cell lung cancer were involved. Pemetrexed was given at a dose of 500 mg/m2 ,followed by eisplatin at a dose of 75 mg/m2. [ Results] Total efficacy was 38.2%. Among them the efficacy of the patients with current advanced non - small cell lung cancer was 43.7% ,but the efficacy of recurrent patients was 33.3%. The main toxicities included bone marrow suppression, nausea and vomiting, constipation, etc. [ Conclusion ] Pemetrexed plus cisplatin is an effective regiment for advanced NSCLC with tolerable side - effect.
出处
《大连医科大学学报》
CAS
2012年第3期284-286,共3页
Journal of Dalian Medical University
关键词
非小细胞肺癌
培美曲塞
顺铂
non- small cell lung cancer
pemetrexed
cisplatin
