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Menin蛋白生物学功能的研究进展

Progress of the biological roles of Menin
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摘要 Menin蛋白为MEN1基因的表达产物,而MEN1基因的突变是遗传性多发性内分泌腺瘤病的致病原因。Menin蛋白具有多种生物学作用,可影响胚胎的生长发育,与肿瘤的发生和生长又密切相关。本文对Menin蛋白生物学功能研究进展进行综述。 Menin is a protein encoded by the gene multiple endocrine neoplasia type 1 （MEN1） , mutations of which are the predominant cause for hereditary MEN1 syndrome. Menin plays various biological roles, affecting embryo growth and development, and is closely related to the occurrence and growth of the tumor. This paper reviews the progress of biological function of Menin protein.
作者 王宇驰 侯蔷 于胜波
机构地区 大连医科大学 大连医科大学解剖学教研室
出处 《大连医科大学学报》 CAS 2012年第3期304-307,共4页 Journal of Dalian Medical University
关键词 MENIN蛋白 MEN1 肿瘤抑制基因 Menin protein multiple endocrine neoplasia type 1 tumor suppressor gene
分类号 R739.45 [医药卫生—肿瘤]
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参考文献29

  • 1Lsson C, Skogseid B, Oberg K, et al. Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma [ J]. Nature, 1988, 1038 (10) :85 - 87.
  • 2Agarwal SK, Lee Burns A, Sukhodolets KE, et al. Molec- ular pathology of the MEN1 gene [J]. Ann N Y Acad Sei, 2004, 1014:189 - 198.
  • 3Khodaei S, OBrien KP, Dumanski J, et al. Characteriza- tion of the MEN1 ortholog in zebrafish [ J]. Biochem Bio- phys Res Commun, 1999, 264(2):404-408.
  • 4Ratineau C, Bernard C, Poncet G, et al. Reduction of me- nin expression enhances cell proliferation and is tumorigen- ic in intestinal epithelial cells [ J ]. J Biol Chem, 2004, 279 ( 23 ) : 24477 - 24484.
  • 5龚龙,薛新波,王从俊.Menin蛋白和TGF-β在甲状旁腺肿瘤中的表达及临床意义[J].临床外科杂志,2005,13(11):698-699. 被引量：2
  • 6Ikeo Y, Sakurai A, Suzuki R, et al. Proliferation -associ- ated expression of the MEN1 gene as revealed by in situ hy- bridization: possible role of the menin as negative regulator of cell proliferation under DNA damage [ J 1. Lab Invest, 2000, 80(6) :797 -804.
  • 7李小英.多内分泌腺瘤病研究进展[J].上海交通大学学报（医学版）,2006,26(1):5-9. 被引量：6
  • 8Ratineau C, Bernard C, Poncet G, et al. Reduction of me- nin expression enhances cell proliferation and is tumorigen- ic in intestinal epithelial cells [ J ]. J Biol Chem ,2004, 279 ( 23 ) :24477 - 24484.
  • 9Chung IH, Yamaza T, Zhao H, et al. Stem cell property of postmigratory cranial neural grest cells and their utility in alveolar bone regeneration and tooth development [ J J. Stem Cells, 2009, 27 (4) :866 - 877.
  • 10Inoue Y, Hendy GN, Canaff L, et al. Menin interacts with 13 - catenin in osteoblast differentiation [ J ]. Horm Metab Research, 2011,43 ( 3 ) : 183 - 187.

二级参考文献57

  • 1Lemmens I, Van de Ven W J, Kas K, et al. Identification of the multiple endocrine neoplasia type 1 ( MEN1 ) gene [ J]. Hum Mol Genet, 1997,6(7): 1177-1183.
  • 2Bertolino P, Radovanovic I, Casse H, et al. Genetic ablation of tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs[J]. Mech Dev, 2003, 120(5) :549 -560.
  • 3Zhang HL, Luo TH, Feng L, et al. Microarray analysis of gene expression in MEN1 knockout embryoid body reveals genetic events involved in early mouse embryonic development [ J ]. Biochem Biophys Res Commun, 2007, 352(2):456-462.
  • 4Agarwal SK, Lee Burns A, Sukhodolets KE, et al. Molecular pathology of the MEN1 gene [J]. Ann N Y Acad Sci, 2004, 1014 : 189 - 198.
  • 5Fontaniere S, Duvillie B, Scharfmann R, et al. Tumour suppressor menin is essential for development of the pancreatic endocrine ceils [ J]. J Endocrinol,2008, 199(2 ) :287 -298.
  • 6Philipe B, Tong WM, Herrera PL, et al. Pancreatic β cell-specific ablation of the multiple endocrine neoplasia type 1 ( MEN1 ) gene causes full penetrance of insulinoma development in mice [ J ]. Cancer Res, 2003, 63(16):4836-4841.
  • 7Karnik SK, Hughes CM, Gu X, et al. Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kipl and p18INK4c[J]. Proc Natl Acad Sci U S A, 2005, 102(41) :14659 - 14664.
  • 8Harley VR, Clarkson M J, Argentaro A. The molecular action and regulation of the testis-determining factors, SRY ( sex-determining region on the Y chromosome) and SOX9 [ SRY-related high-mobility group (HMG) box 9] [J]. Endocr Rev, 2003, 24(4): 466- 487.
  • 9Friedman RS, Bangur CS, Zasloff EJ, et al. Molecular and immu-nological evaluation of the transcription factor SOX-4 as a lung tumor vaccine antigen[ J]. Immunol, 2004, 172(5) : 100 - 105.
  • 10Aaboe M, Birkenkamp-Demtroder K, Wiuf C, et al. SOX4 expression in bladder carcinoma: clinical aspects and in vitro functional characterization [J]. Cancer Res,2006, 66 ( 7 ) :3434 - 3442.

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大连医科大学学报
2012年 第3期

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