颈动脉粥样硬化斑块的稳定性与缺血性脑血管疾病危险因素的相关研究

Research on stability of carotid atherosclerotic plaques and risk factors of cerebral infarction

目的探讨颈动脉粥样硬化斑块稳定性与缺血性脑血管病危险因素的相关性。方法选取2010年10月-2010年12月在广州军区武汉总医院住院的缺血性脑血管病患者203例为研究对象,应用颈动脉彩色多普勒超声技术检查颈动脉粥样硬化斑块的大小、数目及性质,并评估研究对象脑梗死危险因素,行Logistic回归分析。结果脑梗死危险因素包括性别、年龄、吸烟、高血压、糖尿病、冠心病与高血压性心脏病、低密度脂蛋白、脂蛋白(a)、纤维蛋白原、超敏C反应蛋白及高同型半胱氨酸,均与颈动脉粥样硬化不稳定斑块的形成相关(P<0.05)。并且年龄、糖尿病、冠心病与高血压性心脏病、低密度脂蛋白、纤维蛋白原、同型半胱氨酸等脑梗死危险因素可纳入Logistic回归方程,为颈动脉粥样硬化不稳定斑块形成的独立危险因素。结论年龄、糖尿病、冠心病与高血压性心脏病、低密度脂蛋白、纤维蛋白原、高同型半胱氨酸等缺血性脑血管疾病危险因素是导致颈动脉粥样硬化不稳定斑块形成的独立危险因素。

Objective To probe the relativity between stability of carotid atherosclerotic plaques and risk factors of ischemic cerebrovascular disease. Methods A total of 203 inpatients with ischemic cerebrovascular diseases in Wuhan General Hospital of Guangzhou Military from October 2010 to December 2010 were incladed, and the size, number and nature of carotid atherosclerotic plaques by were detected Color Doppler Ultrasound. We assessed risk factors for patients with cerebral infarction, line Logistic regression analysis. Results Risk foctors including gender, age, smoking, hypertension, diabetes, coronary heart disease and hypertensive heart disease, low-density lipoprotein ,lipoprotein （a） ,fibrinogen, C-reactive protein, serum homocysteine were associated with unstable carotid atheroselerotic plaques （ P 〈 0.05 ）. And such risk foctors as age , diabetes, coronary heart disease and hypertensive heart disease,low-density lipoprotein,fibrinogen and serum homocysteine, included by Logistic regression equations, were considered as independent risk factors for unstable CAS plague. Conclusion Such risk foctors for ischemic cerebrovascular disease as age , diabetes, including coronary heart disease and hypertensive heart disease, low- density lipoprotein , fibrinogen and serum homocysteine are independent for forming unstable carotid atherosclerotic plaques.