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基质金属蛋白酶与脑胶质瘤侵袭性生长的关系

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摘要 研究表明，脑胶质瘤的侵袭性与基质金属蛋白酶（matrixmetalloproteinases，MMPs）密切相关。肿瘤侵袭转移过程是瘤细胞从原发瘤脱离后向周围和（或）远处组织侵袭和转移的过程，涉及瘤细胞穿过细胞外基质（extracelluarmatrix，ECM）屏障、血管壁的基底膜及穿出血管壁进入宿主微环境的过程。实验证明，瘤细胞侵袭转移能力与其诱导产生蛋白酶降解ECM、基底膜的能力密切相关。
作者 王毅 刘志红 王瑞英 焦保华 王小凤
机构地区 沧州市中心医院神经外二科
出处 《脑与神经疾病杂志》 2012年第3期237-239,共3页 Journal of Brain and Nervous Diseases
关键词 基质金属蛋白酶 侵袭性生长 脑胶质瘤 细胞外基质 肿瘤侵袭转移 转移能力 侵袭和转移 宿主微环境
分类号 R739 [医药卫生—肿瘤]
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参考文献16

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二级参考文献16

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脑与神经疾病杂志
2012年 第3期

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