期刊文献+

嗅觉障碍性疾病的相关基因及遗传易感性 被引量:1

原文传递
导出
摘要 嗅觉是人类的一种重要感觉,起着辅助识别、危险预警、增进食欲、影响情绪等重要作用。嗅觉障碍性疾病的发生也同样受到基因水平的调控,深入了解嗅觉障碍性疾病的分子学机制及遗传学特点,对探索嗅觉障碍与基因的关系,从而对嗅觉障碍性疾病进行有效干预和治疗至关重要。本文分别从先天性疾病、神经退行性病变、精神性疾病及炎性疾病4个方面,就其相关基因可能引发嗅觉障碍的分子学机制,以及嗅觉障碍性疾病易感性的遗传学基础来阐述嗅觉障碍与基因的关系。
作者 刘佳 魏永祥
出处 《中华耳鼻咽喉头颈外科杂志》 CAS CSCD 北大核心 2012年第6期518-521,共4页 Chinese Journal of Otorhinolaryngology Head and Neck Surgery
基金 国家自然科学基金,首都医学发展科研基金
  • 相关文献

参考文献38

  • 1Soussi-Yanieostas N, de Castro F, Julliard AK, et al. Anosmin1, defective in the X-linked form of Kallmann syndrome, promotes axonal branch formation from olfactory bulb output neurons. Cell, 2002, 109: 217-228.
  • 2Bouloux PM, Hu Y, MacColl G. Recent advances in the pathogenesis of Kallmann's syndrome. Prog Brain Res, 2002, 141 : 79-83.
  • 3Hardelin JP, Dode C. The complex genetics of Kallmann syndrome: KAL1, FGFR1, FGFS, PROKR2, PROK2, et al. Sex Dev, 2008, 2: 181-193.
  • 4Chung WC, Moyle SS, Tsai PS. Fibroblast growth factor 8 signaling through fibroblast growth factor receptor 1 is required for the emergence of gonadotropin-releasing hormone neurons. Endocrinology, 2008, 149 : 4997-5003.
  • 5Cole LW, Sidis Y, Zhang C, et al. Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophinreleasing hormone deficiency: molecular genetics and clinical spectrum. J Clin Endocrinol Metab, 2008, 93: 3551-3559.
  • 6Zhang C, Ng KL, Li JD, et al. Prokineticin 2 is a target gene of proneural basic helix-loop-helix factors for olfactory bulb neurogenesis. J Biol Chem, 2007, 282: 6917-6921.
  • 7Ng KL, Li JD, Cheng MY, et al. Dependence of olfactory bulb neurogenesis on prokinetiein 2 signaling. Science, 2005, 308: 1923-1927.
  • 8Jongmans MC, van Ravenswaaij-Arts CM, Pitteloud N, et al. CHD7 mutations in patients initially diagnosed with Kallmann syndrome- the clinical overlap with CHARGE syndrome. Clin Genet, 2009, 75 : 65-71.
  • 9Ryan AK, Goodship JA, Wilson DI, et al. Spectrum of clinical features associated with interstitial chromosome 22q11 deletions: a European collaborative study. J Med Genet, 1997, 34:798-804.
  • 10Sobin C, Kiley-Brabeck K, Dale K, et al. Olfactory disorder in children with 22q11 deletion syndrome. Pediatrics, 2006, 118 : 697 -703.

二级参考文献24

  • 1顾之燕,董震.变应性鼻炎的诊治原则和推荐方案(2004年,兰州)[J].中华耳鼻咽喉头颈外科杂志,2005,40(3):166-167. 被引量:1708
  • 2Lee JH,Yu HH,Wang LC,et al.The levels of CD4+ CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma.Clin Exp Immunol,2007,148:53-63.
  • 3Provoost S,Maes T,van Durme YM,et al.Decreased FOXP3 protein expression in patients with asthma.Allergy,2009,64:1539-1546.
  • 4Lee SM,Gao B,Dalai M,et al.Decreased FoxP3 gene expression in the nasal secretions from patients with allergic rhinitis.Otolaryngol Head Neck Surg,2009,140:197-201.
  • 5Vercelli D.Discovering susceptibility genes for asthma and allergy.Nat Bev Immunol,2008,8:169-182.
  • 6Zhang L,Han D,Huang D,et al.Prevalence of self-reported allergic rhinitis in eleven major cities in china.Int Arch Allergy Immunol,2009,149:47-57.
  • 7Hori S,Nomura T,Sakaguchi S.Control of regulatory T cell development by the transcription factor Foxp3.Science,2003,299:1057-1061.
  • 8International HapMap Consortium.A haplotype map of the human genome.Nature,2005,437:1299-1320.
  • 9Barrett JC,Fry B,Maller J,et al.Haploview:analysis and visualization of LD and haplotype maps.Bioinformatics,2005,21:263-265.
  • 10Chatila TA,Blaeser F,Ho N,et al.JM2,encoding a fork headrelated protein.is mutated in X-linked autoimmunity-allergic disregulation syndrome.J Clin Invest,2000,106:R75-81.

共引文献4

同被引文献15

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部