摘要
嗅觉是人类的一种重要感觉,起着辅助识别、危险预警、增进食欲、影响情绪等重要作用。嗅觉障碍性疾病的发生也同样受到基因水平的调控,深入了解嗅觉障碍性疾病的分子学机制及遗传学特点,对探索嗅觉障碍与基因的关系,从而对嗅觉障碍性疾病进行有效干预和治疗至关重要。本文分别从先天性疾病、神经退行性病变、精神性疾病及炎性疾病4个方面,就其相关基因可能引发嗅觉障碍的分子学机制,以及嗅觉障碍性疾病易感性的遗传学基础来阐述嗅觉障碍与基因的关系。
出处
《中华耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2012年第6期518-521,共4页
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
基金
国家自然科学基金,首都医学发展科研基金
参考文献38
-
1Soussi-Yanieostas N, de Castro F, Julliard AK, et al. Anosmin1, defective in the X-linked form of Kallmann syndrome, promotes axonal branch formation from olfactory bulb output neurons. Cell, 2002, 109: 217-228.
-
2Bouloux PM, Hu Y, MacColl G. Recent advances in the pathogenesis of Kallmann's syndrome. Prog Brain Res, 2002, 141 : 79-83.
-
3Hardelin JP, Dode C. The complex genetics of Kallmann syndrome: KAL1, FGFR1, FGFS, PROKR2, PROK2, et al. Sex Dev, 2008, 2: 181-193.
-
4Chung WC, Moyle SS, Tsai PS. Fibroblast growth factor 8 signaling through fibroblast growth factor receptor 1 is required for the emergence of gonadotropin-releasing hormone neurons. Endocrinology, 2008, 149 : 4997-5003.
-
5Cole LW, Sidis Y, Zhang C, et al. Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophinreleasing hormone deficiency: molecular genetics and clinical spectrum. J Clin Endocrinol Metab, 2008, 93: 3551-3559.
-
6Zhang C, Ng KL, Li JD, et al. Prokineticin 2 is a target gene of proneural basic helix-loop-helix factors for olfactory bulb neurogenesis. J Biol Chem, 2007, 282: 6917-6921.
-
7Ng KL, Li JD, Cheng MY, et al. Dependence of olfactory bulb neurogenesis on prokinetiein 2 signaling. Science, 2005, 308: 1923-1927.
-
8Jongmans MC, van Ravenswaaij-Arts CM, Pitteloud N, et al. CHD7 mutations in patients initially diagnosed with Kallmann syndrome- the clinical overlap with CHARGE syndrome. Clin Genet, 2009, 75 : 65-71.
-
9Ryan AK, Goodship JA, Wilson DI, et al. Spectrum of clinical features associated with interstitial chromosome 22q11 deletions: a European collaborative study. J Med Genet, 1997, 34:798-804.
-
10Sobin C, Kiley-Brabeck K, Dale K, et al. Olfactory disorder in children with 22q11 deletion syndrome. Pediatrics, 2006, 118 : 697 -703.
二级参考文献24
-
1顾之燕,董震.变应性鼻炎的诊治原则和推荐方案(2004年,兰州)[J].中华耳鼻咽喉头颈外科杂志,2005,40(3):166-167. 被引量:1708
-
2Lee JH,Yu HH,Wang LC,et al.The levels of CD4+ CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma.Clin Exp Immunol,2007,148:53-63.
-
3Provoost S,Maes T,van Durme YM,et al.Decreased FOXP3 protein expression in patients with asthma.Allergy,2009,64:1539-1546.
-
4Lee SM,Gao B,Dalai M,et al.Decreased FoxP3 gene expression in the nasal secretions from patients with allergic rhinitis.Otolaryngol Head Neck Surg,2009,140:197-201.
-
5Vercelli D.Discovering susceptibility genes for asthma and allergy.Nat Bev Immunol,2008,8:169-182.
-
6Zhang L,Han D,Huang D,et al.Prevalence of self-reported allergic rhinitis in eleven major cities in china.Int Arch Allergy Immunol,2009,149:47-57.
-
7Hori S,Nomura T,Sakaguchi S.Control of regulatory T cell development by the transcription factor Foxp3.Science,2003,299:1057-1061.
-
8International HapMap Consortium.A haplotype map of the human genome.Nature,2005,437:1299-1320.
-
9Barrett JC,Fry B,Maller J,et al.Haploview:analysis and visualization of LD and haplotype maps.Bioinformatics,2005,21:263-265.
-
10Chatila TA,Blaeser F,Ho N,et al.JM2,encoding a fork headrelated protein.is mutated in X-linked autoimmunity-allergic disregulation syndrome.J Clin Invest,2000,106:R75-81.
共引文献4
-
1闫舒,张念凯,李娜.变应性鼻炎发病机制及影响因素的研究进展[J].中国中西医结合耳鼻咽喉科杂志,2011,19(5):374-376. 被引量:11
-
2李霁,韩斐.258例抽动障碍与慢性鼻炎共存的发病机制探讨[J].世界科学技术-中医药现代化,2013,15(6):1364-1369. 被引量:13
-
3刘夫红,陈振萍,马静瑶,魏沄沄,吴润晖.FOXP3基因多态性与儿童ITP发病及进展的相关性研究[J].首都医科大学学报,2014,35(5):539-544. 被引量:5
-
4宋秋灵.FOXP3基因多态性与变应性鼻炎的相关性研究[J].国际免疫学杂志,2016,39(2):139-142.
同被引文献15
-
1王艳辉.硝苯地平缓释片致嗅觉丧失[J].药物不良反应杂志,2008,10(5):369-369. 被引量:3
-
2李旺彦.静脉滴注阿奇霉素引起嗅觉障碍一例[J].山西医药杂志(上半月),2011,40(1):87-87. 被引量:2
-
3王海莲.苯磺酸氨氯地平片引起嗅觉、味觉异常1例[J].中国药物警戒,2011,8(6):378-378. 被引量:5
-
4王虎军,徐阳.阿奇霉素致嗅觉和味觉障碍[J].药物不良反应杂志,2011,13(4):251-252. 被引量:2
-
5李馨艳,费小非,杨梅.西妥昔单抗引起味觉、嗅觉丧失1例[J].中国新药杂志,2013,22(7):857-858. 被引量:1
-
6费小非,李馨艳,郑鹿.尼妥珠单抗致嗅觉丧失[J].药物不良反应杂志,2013,15(3):161-162. 被引量:1
-
7吕冬莲,龙萍.莫西沙星致嗅觉和味觉丧失1例[J].中国药师,2013,16(7):1064-1065. 被引量:2
-
8尹珍珍,易俊林,黄晓东,高黎,罗京伟,王凯,曲媛,张世平,肖建平,徐国镇.头颈部肿瘤EGFR单抗疗后罕见嗅觉丧失二例分析[J].中华放射肿瘤学杂志,2014,23(2):140-142. 被引量:2
-
9卢振产,马红岗,何云生,袁玉梅.莫西沙星片致不可逆性嗅觉、味觉损伤1例[J].中国现代应用药学,2015,32(2):217-217. 被引量:2
-
10范艳霞,杜金,王东亚,王红杰.复方利多卡因乳膏预防经鼻插管全身麻醉拔管反应的临床观察[J].河北医药,2016,38(7):998-1000. 被引量:9
-
1魏永祥,韩德民.嗅觉研究现状[J].中国医学文摘(耳鼻咽喉科学),2007,22(4):214-215. 被引量:6
-
2闻不到气味是什么回事[J].家庭医药(就医选药),2004(4):34-34.
-
3郑春泉,刘颖,燕(摘).嗅觉障碍不可忽视[J].健康文摘,2006(11):7-7.
-
4刘丽影.内窥鼻镜下鼻窦炎鼻息肉手术的护理体会[J].吉林医学,2012,33(7):1528-1529. 被引量:1
-
5张卫,孟磊.中西医结合治疗咽异感症70例[J].北方药学,2013,10(12):147-147. 被引量:1
-
6周彤,徐平.阻塞性睡眠呼吸暂停综合征与精神性疾病的研究进展[J].医学综述,2016,22(22):4470-4475. 被引量:1
-
7金占国,程静,韩冰,李洪波,卢宇,李征玥,韩东一.1个DFNA5家系临床遗传学特点及听力学特征分析[J].临床耳鼻咽喉头颈外科杂志,2011,25(9):395-398.
-
8李欣.浅谈过敏性鼻炎的遗传学分析[J].内蒙古中医药,2017,36(2):148-149. 被引量:2
-
9韩明鲲,王秋菊,韩东一.POU3F4基因与X连锁的遗传性聋[J].国际耳鼻咽喉头颈外科杂志,2008,32(3):153-155. 被引量:2
-
10刘承耀,张罗,韩德民.特异性IgE检测及其在变应性疾病诊断中的应用[J].临床耳鼻咽喉头颈外科杂志,2009,23(2):88-92. 被引量:9