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河北磁县贲门腺癌和远端胃腺癌患者肿瘤组织中幽门螺杆菌与EB病毒潜伏膜蛋白1的检出率与胃腺癌发生的关系 被引量:6

Exploration of the association of H. pylori and EBV infection with cardiac and distal gastric adenocarcinoma among residents in Cixian County, a high-risk area of esophgeai cancer in Hebei province
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摘要 目的检测食管癌高发区河北磁县贲门腺癌和远端胃腺癌患者肿瘤组织中幽门螺杆菌(坳)与EB病毒(EBV)的感染情况,探讨其与当地居民胃腺癌发生的关系。方法采用免疫组织化学法检测144例贲门腺癌和46例远端胃腺癌组织中脚与EB病毒潜伏膜蛋白1(EBV-LMP1)的表达,探讨吻和EBV感染与当地居民胃癌发生部位及组织学类型变化的关系。结果贲门腺癌组织中脚的检出率为56.9%,与远端胃腺癌组织中脚的检出率(65.2%)差异无统计学意义(P〉0.05)。在Lauren分型中,肠型远端胃腺癌组织中坳的检出率为71.8%(28/39),显著高于弥漫型远端胃腺癌组织(28.6%,2/7;P〈0.05)。190例胃腺癌组织中,无一例检出EBV-LMP1表达。结论坳和EBV感染与磁县居民胃腺癌发病部位的变化无明显关联,坳感染与磁县居民远端胃腺癌的Lauren分型有关。 Objective To evaluate the H. pylori and Epstein-Barr virus infection in cardiac and distal gastric adenocarcinoma tissues in residents in Cixian county, a high risk area of esophageal cancer in Hebei province, and to explore the putative role of H. pylori and Epstein-Barr virus infection in the carcinogenesis of adenocarcinoma at different subsites of stomach. Methods H. pylori and Epstein-Barr virus latent membrane protein 1 (EBV-LMP1) immunopositivities were determined by EIivisionTM plus immunohistochemical staining in 190 gastric adenocarcinoma tissues including 144 cases of cardiac adenocarcinoma and 46 cases of distal gastric adenocarcinoma. The relationship between H. py/ori and Epstein-Barr virus infection and the subsite, Lauren type as well as other clinicopathological features of gastric adenocarcinoma were analyzed. Results No significant difference was found between the H. pylori detection rates in cardiac and distal gastric adenocarcinomas(56.9% vs. 65.2%, P 〉0.05). The detection rate of H. pylori in intestinal type was significantly higher than that in the diffuse type distal gastric adenocarcinomas (71.8% vs. 28.6% ,P 〈 0.05 ). No positive expression of EBV-LMP1 was found in the gastric adenocarcinomas in this study. Conclusions No significant differences in H. pyloriand EBV-LMPI infections were found between cardiac and distal gastric adenocarcinomas in Cixian county. H. pylori infection is related with the intestinal type of distal gastric adenocarcinoma.
出处 《中华肿瘤杂志》 CAS CSCD 北大核心 2012年第6期446-449,共4页 Chinese Journal of Oncology
关键词 胃肿瘤 幽门螺杆菌 EB病毒潜伏膜蛋白1 免疫组织化学 Stomach neoplasms Helicobacter pyroli, Hp Epstein-Barr virus latent membrane protein 1, EBV-LMP1 Immunohistochemistry
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