创伤后应激障碍脑功能神经影像学研究和进展

Progress of brain functional neuroimaging research in patients with post-traumatic stress disorder

创伤后应激障碍是个体经历严重的创伤性事件(如战争、受虐)后产生的严重的精神障碍。近年来,脑神经影像研究尤其是功能神经影像学研究在创伤后应激障碍中的应用日益增多,功能神经影像技术有利于观察创伤后应激障碍功能脑区以及神经环路的异常。本文综述功能神经影像技术(功能磁共振成像,正电子发射断层扫描,和单光子发射计算机体层扫描)在创伤后应激障碍研究中的重要发现,并提出今后可能的研究方向。

Post-traumatic stress disorder （PTSD） is a serious problem that affects people who have been exposed to the traumatic events （e. g. , combat, childhood abuse）. Over the past several years, there are increasing neuroimaging studies that have focused on this disorder, especially the functional neuroimaging ones. Functional neuroimaging plays an important role in uncovering the abnormal brain regions and neuronal circuitry that mediate PTSD. In this paper, we reviewed the functional neuroimaging findings in patients with PTSD, and suggested possible directions for future research.