新颖的黏细菌模块化天然产物装配线

Novel Characters of Myxobacterial Modular Natural Product Assembly Lines

黏细菌的显著特征之一是能够合成结构多样、功能丰富的天然产物.模块化聚酮合酶(PKS)和非核糖体肽合成酶(NRPS)途径是黏细菌合成天然产物的主要方式.与经典模块PKS/NRPS相比,黏细菌来源的模块化PKS/NRPS常表现出新颖的装配特征,显示出多样化的遗传加工潜能和装配产物结构多样性.本文综合归类分析了黏细菌来源的模块化PKS/NRPS遗传装配线类型及其对应化合物的生化结构特征,图文并茂地呈现了黏细菌在遗传、生化、组合生物合成、进化和药物开发领域的生机和潜能,并展望了基因组学时代带来的契机.

Myxobacteira are noted for their capabilities of synthesizing series of natural products with diverse structures and novel functions. Modular polyketide synthase （PKS） and non ribosomal peptide synthetase （NRPS） are the major natural products ofmyxobacteria. Compared to classical modular PKS/NRPS, myxobacteria modular PKSs/NRPSs usually show novel assembly features, exhibiting diverse genetic assembly potential and abundant product structure varieties. This review classified novel characters of Myxobacterial PKSs/NRPSs assembly lines and further illustrated their corresponding structure features, revealed their vital and potential in genetics, biochemistry, combination biosynthesis, evolution and drug research areas, and also forecasted their opportunities coming with genome era.