颅脑超声对帕金森病的诊断价值

Predictive value of transcranial sonography in the diagnosis of Parkinson disease

目的探索颅脑超声(TCS)对帕金森病(PD)的诊断价值。方法对78例PD患者(PD组)和60名正常人(正常对照组)进行TCS检查,观察中脑回声,并测量中脑黑质回声增强的面积及与中脑面积的比值(S/M)。将中脑黑质面积≥0.20cm2和S/M≥7.00%诊断为PD,记为阳性,中脑黑质面积<0.20cm2或S/M<7.00%记为阴性。结果 PD组78例中,阳性66例,阴性12例;正常对照组60名中,5名为阳性,55名为阴性(P<0.005)。TCS诊断PD的敏感度、特异度、阳性预测值、阴性预测值和准确率分别为92.96%(66/71)、82.09%(55/67)、84.61%(66/78)、91.67%(55/60)、87.68%(121/138)。结论 TCS对辅助诊断PD有一定价值。

Objective To observe the value of transcranial sonography（TCS） for diagnosing Parkinson disease（PD）.Methods Totally 78 PD patients（PD group） diagnosed clinically and 60 normal controls（control group） underwent TCS.The area of hyperechogenicity substantia nigra and midbrain,hyper-substantia nigra/midbrain（S/M） were measured.The substantia nigra area ≥0.20 cm2 and S/M ≥7.00% leaded to a diagnosis of PD recorded as positive,the substantia nigra area 0.20 cm2 or S/M 7.00% leaded to negative.Results Sixty-six patients in PD group and 5 subjects in control group were judged as positive by TCS（P0.005）.The sensitivity,specificity,positive predictive value,negative predictive value and accuracy in diagnosis of PD was 92.96%（66/71）,82.09%（55/67）,84.61%（66/78）,91.67%（55/60） and 87.68%（121/138）,respectively.Conclusion TCS is a valuable assistant tool in the diagnosis of PD.