经颅电刺激对脑平均血流速度影响的meta分析

Transcranial electrical stimulation on cerebral blood flow velocity of the average-meta-analysis of 8 randomized controlled trials

目的:通过meta分析,探讨经颅电刺激对大脑平均血流速度的影响。方法:通过MEDLINE、EMBASE和CBMdisc等数据库检索国内外已发表相关文献。选择治疗组为药物治疗加双乳突部位经颅电刺激,对照组为药物治疗的随机对照试验。由2位评价者分别按上述检索策略收集资料,按纳入标准入选,采用Comprehensive Meta Analysis V2.0软件对大脑平均血流速度进行meta分析。结果:共有8个临床随机对照试验,包括570例受试者纳入分析。经颅电刺激干预使大脑前动脉OR=40.504(95%CI,4.399—372.918)、大脑中动脉OR=30.376(95%CI,7.123—129.539)、大脑后动脉OR=7.398(95%CI,4.909—11.148)、椎动脉OR=14.085(95%CI,4.696—42.249)和基底动脉OR=15.543(95%CI,3.356—72.000)平均血流速度增加的效能约为对照组的40.5、30.4、7.4、14.1和15.5倍。结论:Meta分析结果表明,经颅电刺激能全面地显著地增加大脑各动脉的血流速度和血流量,这将对临床上合理应用物理因子治疗有较好的临床指导作用。

Objection： Through meta analysis, to discuss the change of averaged blood flow rate in brain under transcranial electrical stimulation（TES）. Method： The published pertinent literature home and abroad in the databases, such as MEDLINE, EMBASE and CBMdisc were searched. The test group received drug treatment and TES in the mastoids of both side; The con- trol group received drug treated randomized controlled trial. Two valuator collected data according to the search strategy mentioned above and intaked the standards. Comprehensive Meta Analysis V2.0 was used to analyze the averaged blood flow rate in brain. Result： Eight clinical randomized controlled trials, including 570 persons, were taken into this analysis. TES inter- vention caused increasing of blood flow rate of brain： arteria cerebri anterior OR=40.504（95%CI,4.399--372.918）, arteria cerebri media OR=30.376（95% CI,7.123--129.539）, arteria cerebri posterior OR=7.398（95% CI,4.909-- 11.148）, vertebral artery OR=14.085（95%CI,4.696--42.249） and basilar artery OR=15.543（95%CI,3.356--72.000）. The increased efficient of averaged blood flow rate was about 40.5, 30.4, 7.4, 14.1 and 15.5 times to the control groups. Conclusion： The result of meta analysis indicate that TES can increase the blood flow rate and blood flow volume of each arterial in brain roundly and remarkably, maybe it can direct the use of physical factor treatment in clinic.