云南腾冲地区人群虫媒传染病的血清流行病学研究

Seroepidemiological study on arbovirus infection of hmmn being in Tengchong, Yunnan Province

目的调查云南腾冲地区人群中虫媒病毒抗体，以了解当地虫媒病毒流行情况。方法应用间接免疫荧光试验（IFA）对72例不明发热患者血清中虫媒病毒抗体进行测定，同时选取37名健康体检者作为对照组。结果发热患者血清中乙型脑炎病毒（JEV）、西尼罗病毒（WNV）、基孔肯雅病毒（CHK）、辛德毕斯病毒（SIN）和西部马脑炎病毒（WEE）IgG抗体阳性率依次为41．67％、50．00％、2．78％、1．39％、0．00％；正常人群血清JEV、Ⅵ州抗体阳性率分别为18．92％、32．43％，CHK、SIN、WEEIgG抗体均未检出。21例JEV、聊Ⅳ抗体均为阳性样本的几何平均滴度（GMRT）分别为1：28和1：31。结论该地区存在着黄病毒和甲病毒感染，还可能存在着其他虫媒病毒感染。

Objective To study the prevalence rate of arbevirus antibodies in human being, and to understand the epidemic situation of arbovirus in Tengchong, Yannan Province. Methods Serum antibodies in 72 cases with fever and 37 healthy people as control were detected by immunoiluorescence assay. Results The positive rates of antibodies against Japanese encephalitis virus （JEV）, West nile virus （WNV）, Chikungunya virus （CHK）, Sindbis virus （SIN）, Western equine encephalomyelitis virus（WEE） in these patients were 41.67 %, 50.00%, 2.78 %, 1.39% and 0.00%, respectively. The positive rates of antibodies against JEV and WNV in healthy people were 18.92% and 32.43%, respectively. The geometric mean reciprocal titers（GMRT） in 21 co-positives of JEV and WNV were 1：28 and 1：31, re- spectively. Conclusions The result shows that there are Flavivirus, Alphavirus and other Arbovirus infection in Teng- chong, Yunnan Province.