阻断迷走神经对胆管加压所致心血管活动的影响

Influence of vagal block at different levels on alteration of cardiovascular activity induced by acute hypertension of bile duct

目的 以迷走神经为对象 ,研究胆管加压所致机体心血管活动变化的神经机理。方法 采用自制“盲囊”导管制成家兔急性胆管加压模型 ,观察动物的动脉血压及心输出量改变情况。结果 持续胆道加压 ,家兔的动脉血压和心输出量几乎平行快速下降 (P <0 .0 5 ) ;这种变化在阻断颈部或腹部迷走神经后 ,又很快恢复至加压前水平 (P >0 .0 5 ) ,但动脉血压和心输出量的恢复速度 ,按迷走神经的阻断部位不同而有所差异。结论 胆道高压所致的家兔血液动力学变化 ,与迷走神经的活动有关 ,并且推断可能是一种神经反射机制。

Objective In order to make a further study on the neural mechanism of alteration of cardiovascular activity induced by aute hypertension of bile duct. Methods A model of rabbit's bile duct high pressure was by a self made catheter with an inflatable rubber bag was used and arterial blood pressure (ABP)and cardiac output (CO) was observed during the experiment. Results A significant decrease of ABP and CO was found ( P <0.05) in the animals with simple type acute biliary high pressure. When the abdominal vagi or cervical vagi was blocked, ABP and CO recovered quickly ( P >0.05). But there were differences in terms of different levels of vagal block. Conclusion These results indicate that vagi may play an important neural role in the significant decrease of ABP and CO induced by acute high biliary pressure.