骨性关节炎患者血液流变学的变化及丹参疗效观察

Changes of Hemorrheology and Effects of Salvia Miltiorrhiza Injection on Osteoarthritis

目的探讨骨性关节炎(OA)患者血液流变学的变化及丹参注射液治疗效果。方法对15例OA患者的血液流变学指标进行了较全面的检测 ,并与正常人进行对照分析 ,同时观察丹参注射液治疗OA患者的临床效果及对血液流变学的影响。结果OA组较对照组的全血粘度 ,血浆粘度 ,红细胞压积 ,血小板粘附率 ,红细胞聚集指数 ,纤维蛋白原均明显增加 ;应用丹参注射液治疗OA患者 ,治疗后血液流变学指标明显得到改善 ,有显著性差异(P值分别<0.01 ,0.05) ,以临床治疗效果来看 ,丹参注射液治疗OA患者15例 ,显效5例 ,有效8例 ,无效2例 ,总有效率86.7 %。结论OA患者可伴随血液流变学异常 ,至血液呈高粘滞状态。丹参注射液治疗OA患者安全、有效、方便、价格低廉 ,值得临床推广应用。

Objective To explore the changes of hemorrheology and effects of salvia miltiorrhiza injection on osteoarthritis. Methods The hemorrheology indexes of 15 patiernts with osteoarthritis were determined and compared with controls. The effects of salvia miltiorrhiza injection on osteoarthritis were observed. Result The whole blood viscosity, the plasma viscosity, the hematocrit, the rate of aggregation of platelets, the index of erythrocyte aggregation, the fibrinogen were markedly increassed in osteoarthritis, as compared with those in controls. Patients with osteoarthritis treated by salvia miltiorrhiza injection, the hemorrheologic abnormality indexes were obviously improved, the difference was significant (P<0.01,0.05,respectively).In the treatment group, 5 cases were markedly effective, 8 effective and 2 ineffective, the total effective rate was 86.7%. Conclusion The hemorrheologic abnormalities and hypercoagulation state in osteoarthritis patients were observed. Salvia miltiorrhiza injection was safe,effective, convenient, and cheap in treating osteoarthritis patients, It has a good prospect of clinical application.