摘要
设计合成了 2 1个苯基烯丙基硫醚、亚砜和砜类化合物 ,并对其进行了抗锥体虫半胱氨酸蛋白酶的药理活性筛选 .实验表明化合物 (4) ,(11) ,(15 ) ,(18)和 (2 1)的活性较强 .
Twenty one compounds(phenylallylthio ether,sulfinyl and sulfonyl)were synthesized and their activities against Trypanosoma cruzi in vitro were tested.The result showed that compounds (4),(11),(15),(18)and (21) had good anticruzain activity.
出处
《中国药物化学杂志》
CAS
CSCD
2000年第1期29-32,共4页
Chinese Journal of Medicinal Chemistry