摘要
以氯苯和苯甲酰氯为起始原料 ,经付克反应、还原、氯化 ,再分别与哌嗪、氯乙醇、氯乙酸钠缩合 ,成盐制得盐酸西替利嗪 ,总收率为 2 8 2 % .
Cetirizine hydrochloride was synthesized from chlorobenzene and benzoyl chloride by the Friedel Crafts reaction,reduction,and chlorination followed by condensation with piperizine,2 chloroethanol and sodium chloroacetate in turn in 28 2%overall yield based on chlorobenzene.
出处
《中国药物化学杂志》
CAS
CSCD
2000年第1期66-67,共2页
Chinese Journal of Medicinal Chemistry
关键词
盐酸西替利嗪
抗变态反应
合成
cetirizine hydrochloride
anti allergy
synthesis
