高压氧对兔眼视网膜血流量的影响

The effects of hyperbaric oxygenation on retinal blood flow of rabbits

目的 研究正常兔眼在高压氧 (HBO)治疗结束时及其后不同时程视网膜血流量的变化 ,为 HBO在眼科的应用提供基础数据。方法 采用放射微球标记法分别测在 HBO治疗结束时、出氧舱后1,2 ,4,2 0 h时的视网膜血流量 ,并与对照组比较。结果 HBO治疗结束时 ,平均视网膜血流量由 (16 .87± 4.86 ) m l· min- 1 · g- 1 (对照组值 )降为 (0 .2 1± 0 .0 8) ml· m in- 1 · g- 1 (P<0 .0 1) ;出氧舱后 1h,平均血流量较 HBO治疗结束时明显升高 ,之后持续升高 ,至 4h时恢复正常 (P>0 .0 5 )。结论 HBO治疗后兔眼视网膜血流量明显减少 ,出氧舱后持续 4h的低血流量状态 ,有可能影响视功能。

Objective To study the changes in retinal blood flow of rabbits at the end of and after hyperbaric oxygenation treatment(HBOT). Methods The samples were taken at different times after HBOT, and the blood flow was measured with the radiolabelled microspheres method. Results At the end of HBOT, the mean retinal blood flow was decreased from(16.87±4.86) ml·min -1 ·g -1 (control group) to(0.21±0.08) ml·min -1 ·g -1 ( P <0 01); 1 hour after of HBOT, the blood flow began to increase, and then went on increasing till it returned to normal at 4 hour after HBOT. Conclusions Retinal blood flow is markedly decreased after HBOT, and the 4 hour period of low blood flow after HBOT may impair the visual function.