MR灌注成像联合MR血管造影诊断实验性急性肺栓塞

Diagnosis of Acute Pulmonary Embolism:MR Pulmonary Perfusion Combined with MR Angiography in an Experimental Study

目的 探讨磁共振肺灌注成像(MRPP)联合GdDTPA增强磁共振血管造影(MRA)诊断急性肺栓塞(APE)的可行性及其作用。方法 对10只犬肺栓塞模型,利用2D快速扰相梯度回波序列(2DFSPGR)和3D快速扰相梯度回波序列(3DFSPGR)行MRPP和增强MRA检查,以肺X线血管造影和肺血管解剖为对照,计算MRPP和MRA诊断急性肺栓塞的敏感度,探讨其诊断价值。结果 MRPP和MRA图像质量良好,MRPP显示较大面积灌注不良效果良好,敏感度为652%,MRA诊断外周肺动脉血栓的准确率较高,敏感度达826%。结论 MRPP联合MRA扫描是诊断急性肺栓塞的可行方法,有待于进一步行临床研究。

Objective To probe into the feasibility and value of magnetic resonance pulmonary perfusion (MRPP) combined with Gd DTPA enhanced magnetic resonance angiography (MRA) in the diagnosis of acute pulmonary embolism (APE). Methods Ten dogs with experimental APE were scanned with two dimensional fast spoiled gradient echo sueence (2D FSPGR) to obtain MRPP and contrast enhanced MRA.The images of MRPP and MRA were analyses according to the findings of X ray pulmonary angiography and pathological dissection. Results The quality of MRPP and MRA were good.The sensitivity of MRPP,and MRA was 65.2% and 82.6% respectively. Conclusion MRPP combined with contrast enhanced MRA is a feasible method to diagnose APE,and the clinical investigation should be done in future. [