吡拉西坦对高血压脑出血术后患者的影响

Effect of Piracetam on Patients with Hypertensive Cerebral Hemorrhage after Undergoing Surgery

目的:探讨吡拉西坦对高血压脑出血术后患者的影响。方法:选取2010年1月—2011年12月中国医科大学附属第四医院收治的高血压脑出血患者共160例,以随机抽样法分为实验组和对照组,其中实验组采用20%吡拉西坦氯化钠注射液治疗,对照组采用20%甘露醇注射液治疗。结果:实验组中度脑水肿发生率明显较高(P<0.05),而对照组重度脑水肿发生率明显较高(P<0.05);实验组患者的意识清醒情况明显多于对照组(77.50%vs.62.50%,P<0.05);治疗3个月后实验组巴氏指数(BI)、简明精神状态检查量表(MMSE)评分均明显高于对照组(P<0.05);2组不良反应发生率差异具有统计学意义(P<0.05)。结论:吡拉西坦注射液可代替甘露醇用于高血压脑出血术后降低颅内压,且其具有对脑的保护及促醒作用,不良反应少,在临床上值得推广应用。

OBJECTIVE：To evaluate the effect of piracetam on patients with hypertensive cerebral hemorrhage after undergoing surgery.METHODS： From Jan.2010 to Dec.2011,a total of 160 patients with hypertensive cerebral hemorrhage treated in our hospital were randomly assigned to receive 20% piracetam sodium chloride injection（experimental group） or 20% mannitol injection（control group）.RESULTS： The experiment group had significantly higher incidence of moderate encephaledema yet significantly lower incidence of severe encephaledema than did control group（P〈0.05）.The state of consciousness was better in experimental group than in control group（77.50% vs.62.50%,P〈0.05）.The Barthel index and mini-mental state examination（MMSE） of experiment group were all higher than in control group after 3-month treatment（P〈0.05）.There were significant differences between the two groups in adverse drug reactions（P〈0.05）.CONCLUSION： Piracetam can be used to replace mannitol to reduce intracranial pressure in patients with hypertensive cerebral hemorrhage after operation and it has cerebral protective and awakening effects yet with fewer side effects,which thus is worthy of clinical recommendation.